Cummings Patricia L, Kuo Tony, Javanbakht Marjan, Sorvillo Frank
Division of Chronic Disease and Injury Prevention, Los Angeles County Department of Public Health, Los Angeles, California; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, California
Division of Chronic Disease and Injury Prevention, Los Angeles County Department of Public Health, Los Angeles, California; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, California.
Am J Trop Med Hyg. 2014 Nov;91(5):959-64. doi: 10.4269/ajtmh.14-0287. Epub 2014 Sep 8.
Few studies have quantified toxoplasmosis mortality, associated medical conditions, and productivity losses in the United States. We examined national multiple cause of death data and estimated productivity losses caused by toxoplasmosis during 2000-2010. A matched case-control analysis examined associations between comorbid medical conditions and toxoplasmosis deaths. In total, 789 toxoplasmosis deaths were identified during the 11-year study period. Blacks and Hispanics had the highest toxoplasmosis mortality compared with whites. Several medical conditions were associated with toxoplasmosis deaths, including human immunodeficiency virus (HIV), lymphoma, leukemia, and connective tissue disorders. The number of toxoplasmosis deaths with an HIV codiagnosis declined from 2000 to 2010; the numbers without such a codiagnosis remained static. Cumulative disease-related productivity losses for the 11-year period were nearly $815 million. Although toxoplasmosis mortality has declined in the last decade, the infection remains costly and is an important cause of preventable death among non-HIV subgroups.
在美国，很少有研究对弓形虫病的死亡率、相关医疗状况及生产力损失进行量化。我们研究了全国多死因数据，并估算了2000年至2010年期间弓形虫病所致的生产力损失。一项匹配病例对照分析研究了合并症与弓形虫病死亡之间的关联。在为期11年的研究期间，共确定了789例弓形虫病死亡病例。与白人相比，黑人和西班牙裔的弓形虫病死亡率最高。几种医疗状况与弓形虫病死亡有关，包括人类免疫缺陷病毒（HIV）、淋巴瘤、白血病和结缔组织疾病。2000年至2010年期间，合并HIV诊断的弓形虫病死亡病例数量有所下降；未合并此类诊断的病例数量保持稳定。11年期间与疾病相关的累积生产力损失近8.15亿美元。尽管过去十年弓形虫病死亡率有所下降，但该感染仍然代价高昂，并且是导致非HIV亚组可预防死亡的重要原因。
