Uria Uxue, Vila Carlos, Lin Ming-Yuan, Rueping Magnus
Institute of Organic Chemistry, Institution RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany).
Chemistry. 2014 Oct 20;20(43):13913-7. doi: 10.1002/chem.201403768. Epub 2014 Sep 8.
The enantioselective synthesis of α- and γ-tocopherol (the most biologically active members of vitamin E family) and analogues has been accomplished employing a new enantioselective gold catalyzed intramolecular allylic alkylation reaction followed by an olefin cross-metathesis as key steps. The methodology proved to be applicable to different olefins highlighting its potential for the synthesis of diverse libraries.
利用一种新的对映选择性金催化分子内烯丙基烷基化反应，随后进行烯烃交叉复分解反应作为关键步骤，实现了α-生育酚和γ-生育酚（维生素E家族中生物活性最强的成员）及其类似物的对映选择性合成。该方法被证明适用于不同的烯烃，突出了其在合成多样文库方面的潜力。
