Owotade Foluso J, Patel Mrudula
Division of Oral Microbiology, Department of Oral Biological Sciences, School of Oral Health Sciences, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg, South Africa; Faculty of Dentistry, Obafemi Awolowo University, Ile-Ife, Nigeria.
Division of Oral Microbiology, Department of Oral Biological Sciences, School of Oral Health Sciences, Faculty of Health Sciences, University of The Witwatersrand, Johannesburg, South Africa.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Oct;118(4):455-60. doi: 10.1016/j.oooo.2014.07.004. Epub 2014 Jul 25.
This study compared the virulence of oral Candida species isolated from human immunodeficiency virus (HIV)-positive women with and without oral candidiasis.
Candida species were isolated from 197 women, and their virulence attributes were measured.
Of the 197 women, 117 (59.4%) carried Candida. Of these, 15 (12.8%) had symptoms of oral candidiasis. Among highly active antiretroviral therapy (HAART)-naive patients, 33% were diagnosed with oral candidiasis, whereas 5.9% were asymptomatic carriers (P < .01). C. albicans was the predominant species, with higher virulence attributes than non-albicans Candida. Women diagnosed with oral candidiasis had higher levels of Candida (P = .02) than asymptomatic carriers. There was no difference in the CD4 counts and the virulence attributes of Candida from both the groups.
This study indicates that oral candidiasis is mainly caused by high counts of C. albicans and suggests the importance of therapies targeting Candida counts in the oral cavity even in patients on HAART to reduce the development of infections.
本研究比较了从患有和未患有口腔念珠菌病的人类免疫缺陷病毒（HIV）阳性女性中分离出的口腔念珠菌的毒力。
从197名女性中分离出念珠菌，并测量其毒力特性。
在197名女性中，117名（59.4%）携带念珠菌。其中，15名（12.8%）有口腔念珠菌病症状。在未接受高效抗逆转录病毒治疗（HAART）的患者中，33%被诊断为口腔念珠菌病，而5.9%为无症状携带者（P <.01）。白色念珠菌是主要菌种，其毒力特性高于非白色念珠菌。被诊断为口腔念珠菌病的女性的念珠菌水平高于无症状携带者（P =.02）。两组患者的CD4细胞计数和念珠菌的毒力特性没有差异。
本研究表明，口腔念珠菌病主要由高数量的白色念珠菌引起，并表明即使在接受HAART治疗的患者中，针对口腔念珠菌数量的治疗对于减少感染的发生也很重要。
