Kokpol Chayada, Aekplakorn Wichai, Rajatanavin Natta
Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Dermatol. 2014 Oct;41(10):898-902. doi: 10.1111/1346-8138.12614. Epub 2014 Sep 9.
The prevalence of metabolic syndrome in Asian psoriatic patients compared with that of the general population shows variable results. This study aimed to examine the association between psoriasis and metabolic syndrome in a Thai population. This case-control study included 199 psoriatic patients and 199 controls matched for sex and age from the general Thai population. There were 111 men (55.8%) and 88 women (44.2%) in both the psoriatic and control groups. The mean age (± standard deviation) of both groups was 50.04 ± 13.81 and 49.96 ± 14.39 years (P = 0.91), respectively. The majority of psoriatic cases (82.9%) were of plaque type. The prevalence of metabolic syndrome was significantly higher in psoriatic patients than in the general population at 49.25% versus 30.65%. After controlling for age, sex, smoking and alcohol drinking the odds ratio was 2.25 (P < 0.0001). The metabolic components which were significantly higher in the cases than controls included hyperglycemia, high blood pressure (HBP) and abdominal obesity. No statistically significant difference was found between the cases and controls regarding prevalence of obesity, hypertriglyceridemia and low high-density lipoprotein cholesterol. Thai psoriatic patients had a higher prevalence of metabolic syndrome than the general population. In conclusion, the prevalence of HBP, hyperglycemia and abdominal obesity was significantly higher in cases than in controls.
与普通人群相比，亚洲银屑病患者代谢综合征的患病率呈现出不同的结果。本研究旨在调查泰国人群中银屑病与代谢综合征之间的关联。这项病例对照研究纳入了199例银屑病患者以及199名来自泰国普通人群的、在性别和年龄上相匹配的对照者。银屑病组和对照组中均有111名男性（55.8%）和88名女性（44.2%）。两组的平均年龄（±标准差）分别为50.04±13.81岁和49.96±14.39岁（P = 0.91）。大多数银屑病病例（82.9%）为斑块型。银屑病患者中代谢综合征的患病率显著高于普通人群，分别为49.25%和30.65%。在对年龄、性别、吸烟和饮酒进行校正后，比值比为2.25（P < 0.0001）。病例组中显著高于对照组的代谢指标包括高血糖、高血压（HBP）和腹型肥胖。在肥胖、高甘油三酯血症和低高密度脂蛋白胆固醇的患病率方面，病例组和对照组之间未发现统计学上的显著差异。泰国银屑病患者代谢综合征的患病率高于普通人群。总之，病例组中高血压、高血糖和腹型肥胖的患病率显著高于对照组。
