Ungprasert Patompong, Raksasuk Sukit
Clinical Epidemiology Unit, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkoknoi, Bangkok, 10700, Thailand.
Division of Nephrology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Int Urol Nephrol. 2018 Jul;50(7):1277-1283. doi: 10.1007/s11255-018-1868-z. Epub 2018 Apr 11.
Patients with psoriasis may have a higher risk of developing chronic kidney (CKD) and end-stage renal disease (ESRD) compared with general population. This systematic review and meta-analysis aimed to comprehensively investigate this association by reviewing all available evidence.
A systematic review was performed using MEDLINE and EMBASE database from inception to January 2018 to identify all cohort studies that compared the risk of incident CKD and/or ESRD in patients with psoriasis versus individuals without psoriasis. Pooled risk ratio and 95% confidence interval were calculated using random-effect, generic inverse variance method.
A total of four retrospective cohort studies with 199,808 patients with psoriasis were included. The risk of incident CKD and ESRD was significantly increased among patients with psoriasis with the pooled risk ratio of 1.34 (95% CI, 1.14-1.57) and 1.29 (95% CI, 1.05-1.60), respectively.
A significantly increased risk of incident CKD and ESRD among patients with psoriasis compared with individuals without psoriasis was demonstrated in this study.
与普通人群相比，银屑病患者发生慢性肾脏病（CKD）和终末期肾病（ESRD）的风险可能更高。本系统评价和荟萃分析旨在通过回顾所有现有证据全面研究这种关联。
使用MEDLINE和EMBASE数据库进行系统评价，检索从建库至2018年1月的所有队列研究，以比较银屑病患者与非银屑病患者发生CKD和/或ESRD的风险。采用随机效应、通用逆方差法计算合并风险比和95%置信区间。
共纳入4项回顾性队列研究，涉及199,808例银屑病患者。银屑病患者发生CKD和ESRD的风险显著增加，合并风险比分别为1.34（95%CI，1.14 - 1.57）和1.29（95%CI，1.05 - 1.60）。
本研究表明，与非银屑病患者相比，银屑病患者发生CKD和ESRD的风险显著增加。
