钌（II）催化的异氰酸酯参与的C-H活化反应：一种合成邻苯二甲酰亚胺的通用方法。
Ruthenium(II)-catalyzed C-H activation with isocyanates: a versatile route to phthalimides.
作者信息
De Sarkar Suman, Ackermann Lutz
机构信息
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, 37077 Göttingen (Germany), Fax: (+49) 551-39-6777.
出版信息
Chemistry. 2014 Oct 20;20(43):13932-6. doi: 10.1002/chem.201404261. Epub 2014 Sep 8.
A cationic ruthenium(II)-complex was utilized in the efficient synthesis of phthalimide derivatives by C-H activation with synthetically useful amides. The reaction proceeded through a mechanistically unique insertion of a cycloruthenated species into a C-Het multiple bond of isocyanate. The novel method also proved applicable for the synthesis of heteroaromatic unsymmetric diamides as well as a potent COX-2 enzyme inhibitor.
一种阳离子钌（II）配合物被用于通过与具有合成价值的酰胺进行C-H活化来高效合成邻苯二甲酰亚胺衍生物。该反应通过环钌化物种以一种独特的机理插入异氰酸酯的C-Het多重键来进行。这种新方法还被证明适用于合成杂芳族不对称二酰胺以及一种有效的COX-2酶抑制剂。
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