通过钌催化的氧化 C-H/O-H 键断裂实现异香豆素和 α-吡喃酮的多功能合成。
Versatile synthesis of isocoumarins and α-pyrones by ruthenium-catalyzed oxidative C-H/O-H bond cleavages.
机构信息
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen, Germany.
出版信息
Org Lett. 2012 Feb 3;14(3):930-3. doi: 10.1021/ol2034614. Epub 2012 Jan 24.
PMID:22273364
Abstract
An inexpensive cationic ruthenium(II) catalyst enabled the expedient synthesis of isocoumarins through oxidative annulations of alkynes by benzoic acids. This C-H/O-H bond functionalization process also proved applicable to the preparation of α-pyrones and was shown to proceed by rate-limiting C-H bond ruthenation.
摘要
一种廉价的阳离子钌（II）催化剂可通过炔烃与苯甲酸的氧化环化迅速合成异香豆素。这种 C-H/O-H 键官能团化过程也适用于α-吡喃酮的制备，且反应过程受 C-H 键钌化的速率限制。
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