通过 Rh(III)催化的异氰酸酯与芳基和乙烯基 C-H 键的酰胺化反应，简便合成 N-酰基邻苯二甲酰亚胺和β-烯胺酰胺。
Expedient synthesis of N-acyl anthranilamides and β-enamine amides by the Rh(III)-catalyzed amidation of aryl and vinyl C-H bonds with isocyanates.
机构信息
Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA.
出版信息
J Am Chem Soc. 2011 Aug 3;133(30):11430-3. doi: 10.1021/ja203495c. Epub 2011 Jul 8.
Abstract
A Rh(III)-catalyzed protocol for the amidation of anilide and enamide C-H bonds with isocyanates has been developed. This method provides direct and efficient syntheses of N-acyl anthranilamides, enamine amides, and pyrimidin-4-one heterocycles.
摘要
发展了一种 Rh(III)催化的异氰酸酯与酰苯胺和烯酰胺 C-H 键酰胺化的反应方法。该方法为 N-酰基邻苯二甲酰亚胺、烯胺酰胺和嘧啶-4-酮杂环化合物的直接高效合成提供了新途径。
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