钴（III）催化的碳氢键与异氰酸酯的酰胺化反应。
Cobalt(III)-Catalyzed C-H Bond Amidation with Isocyanates.
作者信息
Hummel Joshua R, Ellman Jonathan A
机构信息
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520-8107, United States.
出版信息
Org Lett. 2015 May 15;17(10):2400-3. doi: 10.1021/acs.orglett.5b00910. Epub 2015 May 6.
Abstract
The first examples of cobalt(III)-catalyzed C-H bond addition to isocyanates are described, providing a convergent strategy for arene and heteroarene amidation. Using a robust air- and moisture-stable catalyst, this transformation demonstrates a broad isocyanate scope and good functional-group compatibility and has been performed on gram scale.
摘要
首次报道了钴(III)催化的异氰酸酯与C-H键加成反应的实例，为芳烃和杂芳烃酰胺化反应提供了一种汇聚式策略。使用一种稳定的、对空气和湿气稳定的催化剂，该转化反应展示了广泛的异氰酸酯范围和良好的官能团兼容性，并且已在克级规模上进行。
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