Kostopoulos T C, Krishna S M, Brinster N K, Ortega-Loayza A G
Department of Dermatology, Virginia Commonwealth University Medical Center, Richmond, VA, USA.
J Eur Acad Dermatol Venereol. 2015 Feb;29(2):209-214. doi: 10.1111/jdv.12721. Epub 2014 Sep 8.
Acute generalized exanthematous pustulosis (AGEP) is an acute drug eruption characterized by erythematous plaques and papules studded with numerous, pinpoint pustules. Several atypical clinical presentations and triggers of AGEP have been described in the literature. These include systemic presentations similar to toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome (DIHS) and localized presentations mimicking other medication reactions. We herein aim to review atypical presentations and medication triggers of AGEP to assist clinicians in recognizing this condition and making appropriate therapeutic interventions.
急性泛发性发疹性脓疱病（AGEP）是一种急性药物疹，其特征为红斑性斑块和丘疹上布满无数细小脓疱。文献中已描述了AGEP的几种非典型临床表现和诱发因素。这些包括类似于中毒性表皮坏死松解症（TEN）和药物性超敏反应综合征（DIHS）的全身性表现，以及模仿其他药物反应的局限性表现。我们在此旨在综述AGEP的非典型表现和药物诱发因素，以帮助临床医生识别这种疾病并进行适当的治疗干预。
