Mercogliano Christopher, Khan Muhammad, Lin Catherine, Mohanty Elan, Zimmerman Ryan
Department of Internal Medicine, Reading Hospital and Medical Center, Tower Health, Reading, PA, USA.
J Community Hosp Intern Med Perspect. 2018 Dec 11;8(6):360-362. doi: 10.1080/20009666.2018.1547089. eCollection 2018.
Acute Generalized Exanthematous Pustulosis (AGEP) is a rare drug reaction manifesting as pustular lesions with surrounding erythema following exposure. The disease is often self-limited and treatment is supportive. It may present in an atypical variant with vesicles that desquamate into erosions, which classifies the disease as an AGEP/SJS Overlap. This overlap syndrome can carry a substantial mortality rate and necessitate elevation in the level of care. Hydroxychloroquine has been implicated in cases of AGEP, and we present a case of AGEP/SJS overlap attributed to this common medication. Given the prevalence of drug eruptions, it is critical for the physicians to recognize and not overlook this rare and potentially fatal dermatological emergency.
急性泛发性脓疱性皮病（AGEP）是一种罕见的药物反应，表现为接触后出现伴有周围红斑的脓疱性损害。该病通常为自限性，治疗以支持治疗为主。它可能以非典型变体形式出现，有脱屑形成糜烂的水疱，这将该疾病归类为AGEP/Stevens-Johnson综合征重叠型。这种重叠综合征可能具有较高的死亡率，需要提高护理级别。羟氯喹已被认为与AGEP病例有关，我们报告一例归因于这种常用药物的AGEP/Stevens-Johnson综合征重叠型病例。鉴于药物疹的普遍性，医生认识到并不过度忽视这种罕见且可能致命的皮肤急症至关重要。
