Ylikoski Ari, Martikainen Kirsti, Partinen Markku
Vitalmed Research Center, Helsinki Sleep Clinic, Helsinki, Finland; Hospital of Laakso, Department of Neurology, Helsinki, Finland.
The Finnish Parkinson Association, The Finnish Parkinson Foundation, Turku, Finland.
J Neurol Sci. 2014 Nov 15;346(1-2):204-8. doi: 10.1016/j.jns.2014.08.025. Epub 2014 Aug 27.
Sleep disorders are among the most common non-motor symptoms in Parkinson's disease.
The prevalence of parasomnias and their association with other symptoms were studied in a questionnaire study among 1447 randomly selected Parkinson patients, aged 43 to 89 years. The response rate was 59.0% and of these 77% had answered to all questions that were used in the analyses (N = 661).
The prevalence of REM sleep behavior disorder (RBD) evaluated by the RBDSQ ≥ 6 was 39.0%. The occurrences of other parasomnias (≥ 1/week) in patients with PD were: nightmares 17.2%, night terrors 3.9%, sleepwalking 1.8%, enuresis 21.0%, and hallucinations 15.3%. Occurrences (≥ 1/week) of the isolated sleep symptoms were: nocturnal sweating 28.8%, bruxism 4.7%, and sleep talking 21.7%. Association of RBD with sleepwalking (parasomnia overlap disorder) was found in 1.7% of all PD patients. Adjusted logistic regression analysis showed that weekly nightmares (OR 12.5; 95% CI 5.3 to 29.7), hallucinations (OR 5.1; 2.1 to 12.4), sleep talking (OR 11.6; 5.9 to 22.8), male gender (OR 1.9; 1.1 to 3.1), and restless legs syndrome (OR 4.7; 1.7 to 13.2) associated with the presence of RBD.
Parkinson patients with RBD have often also other parasomnias and/or isolated sleep symptoms.
睡眠障碍是帕金森病最常见的非运动症状之一。
在一项问卷调查研究中，对1447名年龄在43至89岁之间随机选取的帕金森病患者进行了异态睡眠的患病率及其与其他症状的关联研究。应答率为59.0%，其中77%回答了分析中使用的所有问题（N = 661）。
通过快速眼动睡眠行为障碍筛查问卷（RBDSQ）≥6评估的快速眼动睡眠行为障碍（RBD）患病率为39.0%。帕金森病患者中其他异态睡眠（≥每周1次）的发生率为：噩梦17.2%，夜惊3.9%，梦游1.8%，遗尿21.0%，幻觉15.3%。孤立性睡眠症状（≥每周1次）的发生率为：夜间出汗28.8%，磨牙4.7%，梦呓21.7%。在所有帕金森病患者中，1.7%发现RBD与梦游（异态睡眠重叠障碍）有关。校正后的逻辑回归分析显示，每周出现噩梦（比值比[OR]12.5；95%置信区间[CI]5.3至29.7）、幻觉（OR 5.1；2.1至12.4）、梦呓（OR 11.6；5.9至22.8）、男性（OR 1.9；1.1至3.1）和不安腿综合征（OR 4.7；1.7至13.2）与RBD的存在相关。
患有RBD的帕金森病患者通常还伴有其他异态睡眠和/或孤立性睡眠症状。
