Zhu Xi-Chen, Yu Yang, Wang Hui-Fu, Jiang Teng, Cao Lei, Wang Chong, Wang Jun, Tan Chen-Chen, Meng Xiang-Fei, Tan Lan, Yu Jin-Tai
Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China.
Department of Neurology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China.
J Alzheimers Dis. 2015;44(1):163-74. doi: 10.3233/JAD-141377.
Many studies reported that physiotherapy interventions are available to treat Alzheimer's disease (AD), but the efficacy remains uncertain.
To evaluate the effectiveness of physiotherapy intervention on AD.
The data sources were searched from literature databases, journals, and reference lists from 1 January 1990 to the end of 1 April 2014. Randomized and non-randomized controlled trials with physiotherapy intervention were included in our meta-analysis. Jadad score and Newcastle-Ottawa scale were used to assess the quality of included trials. Outcome measures were cognition function, physical function, activity of daily life (ADL) and neuropsychiatric inventory (NPI).
23 trials met the inclusion standard finally. Significant changes were seen in cognitive function: Mini-Mental State Examination score (weighted mean difference (WMD): 1.84, 95% confidence interval (CI): [0.76, to, 2.93], p < 0.0001), and verbal fluency (standard mean difference (SMD): 0.34, 95% CI: [0.01 to 0.66], p = 0.04). Other outcomes are also significant, they were timed up and go test (SMD: 0.56, 95% CI: [0.30 to 0.83], p < 0.0001), berg functional balance scale (SMD: 1.11, 95% CI: [0.37 to 1.84], p = 0.003), 6-min walk distance test (SMD: 141.45, 95% CI: [11.72 to 271.18], p = 0.03), ADL (SMD: 0.78, 95% CI: [0.33 to 1.23], p = 0.0007) and NPI (SMD: -0.69, 95% CI: [-1.31 to -0.07], p = 0.03).
The available data indicate that physiotherapy intervention may have benefits in AD. However, current data are not definitive; more carefully designed and conducted observational studies are needed to definitively establish that whether physiotherapy intervention can effectively alleviate symptoms of AD.
许多研究报告称，有物理治疗干预措施可用于治疗阿尔茨海默病（AD），但其疗效仍不确定。
评估物理治疗干预对AD的有效性。
数据来源为1990年1月1日至2014年4月底的文献数据库、期刊及参考文献列表。纳入我们荟萃分析的是采用物理治疗干预的随机和非随机对照试验。使用Jadad评分和纽卡斯尔-渥太华量表评估纳入试验的质量。结局指标为认知功能、身体功能、日常生活活动能力（ADL）和神经精神量表（NPI）。
最终有23项试验符合纳入标准。认知功能出现显著变化：简易精神状态检查表评分（加权均数差（WMD）：1.84，95%置信区间（CI）：[0.76，至，2.93]，p<0.0001），以及语言流畅性（标准化均数差（SMD）：0.34，95%CI：[0.01至0.66]，p = 0.04）。其他结局指标也有显著变化，它们分别是计时起立行走测试（SMD：0.56，95%CI：[0.30至0.83]，p<0.0001）、伯格功能平衡量表（SMD：1.11，95%CI：[0.37至1.84]，p = 0.003）、6分钟步行距离测试（SMD：141.45，95%CI：[11.72至271.18]，p = 0.03）、ADL（SMD：0.78，95%CI：[0.33至1.23]，p = 0.0007）和NPI（SMD：-0.69，95%CI：[-1.31至-0.07]，p = 0.03）。
现有数据表明物理治疗干预可能对AD有益。然而，目前的数据并不确凿；需要更精心设计和实施的观察性研究来明确确定物理治疗干预是否能有效缓解AD的症状。
