Department of Radiation Oncology, Gunma Prefectural Cancer Center, Gunma, Japan
Gunma University Heavy Ion Medical Center, Gunma University, Gunma, Japan.
Anticancer Res. 2014 Sep;34(9):5099-104.
To evaluate dosimetric differences between carbon ion radiotherapy (C-ion RT) and stereotactic body radiotherapy (SBRT) for stage I non-small cell lung cancer (NSCLC).
Thirteen stage I NSCLC cases were planned with C-ion RT and SBRT. Prescription of the dose and fractionation (fr) for stage IA and IB in C-ion RT were 52.8 Gy (RBE)/4fr and 60.0 Gy (RBE)/4fr, respectively and those in SBRT were 52.8 Gy/4fr and 60.0 Gy/4fr, respectively.
The conformity index (CI) for planning target volume of C-ion RT was significantly lower than that of SBRT. The normal lung doses in C-ion RT were significantly lower those that in SBRT. In particularly, for a larger tumor, C-ion RT was lower CI and normal lung dose than SBRT.
C-ion RT has an advantage in both target conformity and sparing of normal lung in stage I NSCLC.
评估碳离子放疗（C 离子放疗）与立体定向体部放疗（SBRT）治疗Ⅰ期非小细胞肺癌（NSCLC）的剂量学差异。
对 13 例Ⅰ期 NSCLC 患者分别进行 C 离子放疗和 SBRT 计划。C 离子放疗中ⅠA 期和ⅠB 期处方剂量及分割次数分别为 52.8Gy（RBE）/4 次和 60.0Gy（RBE）/4 次，SBRT 则分别为 52.8Gy/4 次和 60.0Gy/4 次。
C 离子放疗计划靶区的适形指数（CI）明显低于 SBRT。C 离子放疗的正常肺剂量明显低于 SBRT。特别是对于较大的肿瘤，C 离子放疗的 CI 和正常肺剂量均低于 SBRT。
C 离子放疗在Ⅰ期 NSCLC 中具有更好的靶区适形性和保护正常肺组织的优势。
