Yang Xue-Li, Lu San-Jun, Xue Jie, Wu Yan-Fen, Shi Jun-Ling
Department of Pathology, The First Hospital of Handan City, Handan, Hebei 056002, P.R. China.
Oncol Lett. 2014 Oct;8(4):1625-1627. doi: 10.3892/ol.2014.2372. Epub 2014 Jul 22.
Clear cell sarcoma of soft tissues is a very rare, malignant soft tissue tumor that usually arises in the extremities, with a predilection for the lower limbs. This report presents a 45-year-old male with a painless mass in the right lumbar region for one year. Magnetic resonance imaging showed a 3.6×3.2×1.5-cm soft tissue mass of the right lumbar region. The tumoral cells had pleomorphic nuclei and large amounts of clear cytoplasm, and a proportion of the cells contained melanin. Immunohistochemical analysis was performed, which identified that the cells were positive for S-100, MITF and HMB-45 tumor markers. The patient underwent a postoperative chemotherapy protocol and had no local recurrences at one year post-surgery.