Correia Sílvia da Silva, Pinto Carlos, Bernardo João
Serviço de Pneumologia. Hospital Sousa Martins. Unidade Local de Saúde. Guarda. Portugal.
Centro de Cirurgia Cardiotorácica. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.
Acta Med Port. 2014 Jul-Aug;27(4):417-21. Epub 2014 Aug 29.
Pulmonary aspergiloma or mycetoma is a saprophytic colonization of a preexisting cavity by aspergilloma. Surgical resection is the only effective long-term treatment, but remains controversial because of the high rate of complications in the perioperative and postoperative time.
Analysis of the experience of a Cardiothoracic Surgery Center for the treatment of pulmonary aspergilloma and evaluation of the prognostic factors after surgery.
Retrospective analysis including all the patients with a diagnosis of pulmonary aspergilloma submitted to surgery for a 10 years period, in a single institution (June 2001-June 2011).
The study included 22 patients (18 men) with a mean age of 51.0 + 17.4 years. Of them, 46% were smokers, 41% were alcoholic and 50% had a previous history of tuberculosis. Most of the patients had a complex aspergilloma (73%) and 17% a simple aspergilloma. The most common presentation was hemoptysis (50%). The common surgical procedure performed was atypical lung resection in 55%, lobectomy in 27% and pneumectomy in 9%. Two patients were submitted to thoracoplasty. There was one operative death (5%). Postoperative complications occurred in 36% and the most frequent were pneumothorax (18%) and empyema (18%). The mean follow-up period was 52 months (3 - 116) and the 5 years mortality rate of 35%. Of them, 4 patients died because of non-related causes and 3 were immunosuppressed patients. The mortality was 40% in the group of complex aspergilloma and 33% in the group of complex aspergilloma.
The most common surgical procedure performed was atypical lung resection. The postoperative complications rate was similar to previous studies.
Surgical resection of aspergilloma presents a low morbidity and mortality. Therefore, for patients with lung function preserved, it is the preferred treatment.
肺曲菌球或真菌球是曲霉菌在已存在的空洞内腐生性定植。手术切除是唯一有效的长期治疗方法,但由于围手术期和术后并发症发生率高,仍存在争议。
分析心胸外科中心治疗肺曲菌球的经验,并评估术后预后因素。
回顾性分析在单一机构(2001年6月至2011年6月)10年间所有诊断为肺曲菌球并接受手术治疗的患者。
该研究纳入22例患者(18例男性),平均年龄51.0±17.4岁。其中,46%为吸烟者,41%有酗酒史,50%有肺结核病史。大多数患者为复杂性曲菌球(73%),17%为单纯性曲菌球。最常见的表现是咯血(50%)。常见的手术方式为非典型肺切除术占55%,肺叶切除术占27%,全肺切除术占9%。2例患者接受胸廓成形术。有1例手术死亡(5%)。术后并发症发生率为36%,最常见的是气胸(18%)和脓胸(18%)。平均随访期为52个月(3 - 116个月),5年死亡率为35%。其中,4例患者死于非相关原因,3例为免疫抑制患者。复杂性曲菌球组死亡率为40%,单纯性曲菌球组死亡率为33%。
最常见的手术方式为非典型肺切除术。术后并发症发生率与以往研究相似。
曲菌球手术切除的发病率和死亡率较低。因此,对于肺功能良好的患者,是首选的治疗方法。