Noda J, Umeda S, Arai T, Harima A, Mori K
Department of Anesthesiology, Faculty of Medicine, Kyoto University, Japan.
Clin J Pain. 1989 Jun;5(2):147-52. doi: 10.1097/00002508-198906000-00004.
The continuous subcutaneous infusion of buprenorphine, a new approach to the relief of severe cancer pain, has been carried out using a portable infusion pump. The efficacy of this method was examined in 30 patients by visual analogue scale. An infusion rate of 4 micrograms/kg/day following intramuscular administration of 0.004 micrograms/kg gave satisfactory pain relief without serious complications. The minimum effective blood concentration was not detectable by high-performance liquid chromatography. Advantages of this therapy are its simplicity, applicability in many types of cancer, multiple sites of administration, and easier training on the part of health personnel.
使用便携式输液泵对癌症剧痛患者进行皮下持续输注丁丙诺啡是一种新的止痛方法。采用视觉模拟评分法对30例患者进行了该方法疗效的评估。肌内注射0.004μg/kg后，以4μg/（kg·d）的输注速度给药，可有效缓解疼痛，且无严重并发症。高效液相色谱法未检测到最低有效血药浓度。该疗法具有操作简便、适用于多种癌症、给药部位多样、医护人员易于培训等优点。
