Shiri Rahman
Centre of Expertise for Health and Work Ability, and Disability Prevention Centre, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI-00250 Helsinki, Finland.
Muscle Nerve. 2014 Dec;50(6):879-83. doi: 10.1002/mus.24453. Epub 2014 Oct 30.
This study aimed to assess the magnitude of the association between hypothyroidism and carpal tunnel syndrome (CTS). Eighteen studies were included in a random-effects meta-analysis. A meta-analysis of the studies that did not control their estimates for any confounder showed an association between a thyroid disease (hypo- or hyperthyroidism) and CTS (N = 9,573, effect size [ES] = 1.32 (95% confidence interval [CI], 1.04-1.68) and between hypothyroidism and CTS (N = 64,531, ES = 2.15 [95% CI, 1.64-2.83]). When a meta-analysis limited to the studies that controlled their estimates for some potential confounders, the association between a thyroid disease and CTS disappeared (N = 4,799, ES = 1.17 [95% CI, 0.71-1.92], I(2) = 0%), and the effect size for hypothyroidism largely attenuated (N = 71,133, ES = 1.44 [95% CI, 1.27-1.63], I(2) = 0%). Moreover, there was evidence of publication bias. This meta-analysis found only a modest association between hypothyroidism and CTS. Confounding and publication bias may still account for part of the remaining excess risk.
本研究旨在评估甲状腺功能减退症与腕管综合征（CTS）之间关联的程度。18项研究纳入了随机效应荟萃分析。对未对任何混杂因素估计值进行控制的研究进行荟萃分析，结果显示甲状腺疾病（甲状腺功能减退或亢进）与CTS之间存在关联（N = 9573，效应量[ES]=1.32[95%置信区间（CI），1.04 - 1.68]），以及甲状腺功能减退症与CTS之间存在关联（N = 64531，ES = 2.15[95%CI，1.64 - 2.83]）。当荟萃分析仅限于对某些潜在混杂因素估计值进行控制的研究时，甲状腺疾病与CTS之间的关联消失（N = 4799，ES = 1.17[95%CI，0.71 - 1.92]，I² = 0%），甲状腺功能减退症的效应量大幅减弱（N = 71133，ES = 1.44[95%CI，1.27 - 1.63]，I² = 0%）。此外，存在发表偏倚的证据。这项荟萃分析发现甲状腺功能减退症与CTS之间仅有适度关联。混杂因素和发表偏倚可能仍占剩余额外风险的一部分。
