用于检测凝血酶的囊泡适配体传感器。
Vesicular aptasensor for the detection of thrombin.
作者信息
Müller Andreas, König Burkhard
机构信息
Institut für Organische Chemie, Universität Regensburg, 93040 Regensburg, Germany.
出版信息
Chem Commun (Camb). 2014 Oct 28;50(84):12665-8. doi: 10.1039/c4cc05221h.
PMID:25205174
Abstract
Self-assembled phospholipid vesicles are functionalized with thrombin-binding aptamers using a thiol-click reaction. The resulting aptasensors signal the binding of the analyte to the vesicle surface by changes of the emission properties of membrane co-embedded reporter dyes.
摘要
通过硫醇点击反应，用凝血酶结合适体对自组装磷脂囊泡进行功能化。所得的适体传感器通过膜共嵌入报告染料发射特性的变化来指示分析物与囊泡表面的结合。
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