X 射线照射抑制损伤脊髓中的神经胶质瘢痕形成。
X-irradiation for inhibiting glial scar formation in injured spinal cord.
机构信息
Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin 300052, China.
Department of Orthopedics, Tianjin 4th Central Hospital, Tianjin 300140, China.
出版信息
Neural Regen Res. 2013 Jun 15;8(17):1582-9. doi: 10.3969/j.issn.1673-5374.2013.17.006.
X-irradiation has a beneficial effect in treating spinal cord injury. We supposed that X-irradiation could improve the microenvironment at the site of a spinal cord injury and inhibit glial scar formation. Thus, this study was designed to observe the effects of 8 Gy X-irradiation on the injury site at 6 hours and 2, 4, 7, and 14 days post injury, in terms of improvement in the microenvironment and hind limb motor function. Immunohistochemistry showed that the expression of macrophage marker ED-1 and the area with glial scar formation were reduced. In addition, the Basso, Beattie and Bresnahan score was higher at 7 days post injury relative to the other time points post injury. Results indicated that X-irradiation at a dose of 8 Gy can inhibit glial scar formation and alleviate the inflammatory reaction, thereby repairing spinal cord injury. X-irradiation at 7 days post spinal cord injury may be the best time window.
X 射线照射在治疗脊髓损伤方面有有益的效果。我们假设 X 射线照射可以改善脊髓损伤部位的微环境，抑制神经胶质瘢痕形成。因此，本研究旨在观察 8GyX 射线照射对损伤后 6 小时、2、4、7 和 14 天的损伤部位的影响，以改善微环境和后肢运动功能。免疫组织化学显示，巨噬细胞标志物 ED-1 的表达和神经胶质瘢痕形成区域减少。此外，Basso、Beattie 和 Bresnahan 评分在损伤后 7 天高于其他时间点。结果表明，8Gy 的 X 射线照射可以抑制神经胶质瘢痕形成，减轻炎症反应，从而修复脊髓损伤。脊髓损伤后 7 天进行 X 射线照射可能是最佳的时间窗口。
Zotero 插件