Neurosciences Graduate Program, Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, MC 0691, La Jolla, CA, USA.
Neural Regen Res. 2014 Mar 1;9(5):460-1. doi: 10.4103/1673-5374.130056.
The limited axonal growth after central nervous system (CNS) injury such as spinal cord injury presents a major challenge in promoting repair and recovery. The literature in axonal repair has focused mostly on frank regeneration of injured axons. Here, we argue that sprouting of uninjured axons, an innate repair mechanism of the CNS, might be more amenable to modulation in order to promote functional repair. Extrinsic inhibitors of axonal growth modulate axon sprouting after injury and may serve as the first group of therapeutic targets to promote functional repair.
中枢神经系统（CNS）损伤后轴突的生长有限，如脊髓损伤，这对促进修复和恢复提出了重大挑战。轴突修复的文献主要集中在损伤轴突的再生上。在这里，我们认为未受伤轴突的发芽，即 CNS 的固有修复机制，可能更容易受到调节，以促进功能修复。轴突生长的外在抑制剂调节损伤后的轴突发芽，并且可以作为促进功能修复的第一批治疗靶点。
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