University of California San Diego, Department of Neurosciences, 9500 Gilman Drive, MC 0691, La Jolla, CA 92093-0691, USA.
Exp Neurol. 2012 May;235(1):33-42. doi: 10.1016/j.expneurol.2011.05.001. Epub 2011 May 7.
Myelin-associated inhibitors of axon growth, including Nogo, MAG and OMgp, have been the subject of intense research. A myriad of experimental approaches have been applied to investigate the potential of targeting these molecules to promote axonal repair after spinal cord injury. However, there are still conflicting results on their role in axon regeneration and therefore a lack of a cohesive mechanism on how these molecules can be targeted to promote axon repair. One major reason may be the lack of a clear definition of axon regeneration in the first place. Nevertheless, recent data from genetic studies in mice indicate that the roles of these molecules in CNS axon repair may be more intricate than previously envisioned.
髓鞘相关的轴突生长抑制剂，包括 Nogo、MAG 和 OMgp，一直是研究的热点。为了研究靶向这些分子以促进脊髓损伤后的轴突修复的潜力，已经应用了无数的实验方法。然而，关于它们在轴突再生中的作用仍然存在相互矛盾的结果，因此，关于这些分子如何被靶向以促进轴突修复的机制尚不清楚。一个主要原因可能是首先缺乏对轴突再生的明确定义。尽管如此，最近来自小鼠遗传研究的数据表明，这些分子在中枢神经系统轴突修复中的作用可能比以前想象的更为复杂。
