Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran ; Department of Stem Cells and Tissue Engineering, Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Stem Cells and Tissue Engineering, Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran ; Department of Tissue Engineering, School of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Neural Regen Res. 2014 Apr 15;9(8):845-50. doi: 10.4103/1673-5374.131601.
Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was significantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These findings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.
多项研究表明，选择性 5-羟色胺再摄取抑制剂抗抑郁药可在体外和体内促进神经元细胞增殖和增强神经可塑性。有假说认为，选择性 5-羟色胺再摄取抑制剂西酞普兰可促进成年骨髓间充质干细胞的神经元分化。西酞普兰可明显增强由骨髓间充质干细胞分化而来的细胞的神经元特性。在神经基础培养基中，西酞普兰处理的骨髓间充质干细胞的细胞死亡率较对照组降低。此外，与对照组相比，西酞普兰处理的细胞的累计倍增水平显著增加。西酞普兰处理的细胞的 BrdU 掺入也增加。这些发现表明，西酞普兰可通过增加细胞增殖和存活来改善骨髓间充质干细胞的类神经元细胞分化，同时保持其神经元特性。
Zotero 插件