Centre of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur.
Department of Orthopedics and Traumatology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur.
Int J Nanomedicine. 2022 Dec 28;17:6723-6758. doi: 10.2147/IJN.S362144. eCollection 2022.
Peripheral nerve injury (PNI) is a worldwide problem which hugely affects the quality of patients' life. Nerve conduits are now the alternative for treatment of PNI to mimic the gold standard, autologous nerve graft. In that case, with the advantages of electrospun micro- or nano-fibers nerve conduit, the peripheral nerve growth can be escalated, in a better way. In this systematic review, we focused on 39 preclinical studies of electrospun nerve conduit, which include the in vitro and in vivo evaluation from animal peripheral nerve defect models, to provide an update on the progress of the development of electrospun nerve conduit over the last 5 years (2016-2021). The physical characteristics, biocompatibility, functional and morphological outcomes of nerve conduits from different studies would be compared, to give a better strategy for treatment of PNI.
周围神经损伤（PNI）是一个全球性的问题，极大地影响了患者的生活质量。神经导管现在是治疗 PNI 的替代方法，以模拟金标准，自体神经移植。在这种情况下，具有电纺微/纳米纤维神经导管的优点，可以更好地促进周围神经的生长。在这项系统评价中，我们重点关注了 39 项电纺神经导管的临床前研究，包括来自动物周围神经缺损模型的体外和体内评估，以提供过去 5 年（2016-2021 年）电纺神经导管发展的最新进展。不同研究中神经导管的物理特性、生物相容性、功能和形态学结果将进行比较，为 PNI 的治疗提供更好的策略。
