MOE Key Laboratory of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, Guangdong Province, China.
Institute of Cognitive Neuroscience, South China Normal University, Guangzhou, Guangdong Province, China.
Neural Regen Res. 2014 Apr 15;9(8):857-63. doi: 10.4103/1673-5374.131603.
Substance P is an endogenous neurokinin that is present in the central and peripheral nervous systems. The neuropeptide substance P and its high-affinity receptor neurokinin 1 receptor are known to play an important role in the central nervous system in inflammation, blood pressure, motor behavior and anxiety. The effects of substance P in the hippocampus and the marginal division of the striatum on memory remain poorly understood. Compared with the hippocampus as a control, immunofluorescence showed high expression of the substance P receptor, neurokinin 1, in the marginal division of the striatum of normal rats. Unilateral or bilateral injection of an antisense oligonucleotide against neurokinin 1 receptor mRNA in the rat hippocampus or marginal division of the striatum effectively reduced neurokinin 1 receptor expression. Independent of injection site, rats that received this antisense oligonucleotide showed obviously increased footshock times in a Y-maze test. These results indicate that the marginal division of the striatum plays a similar function in learning and memory to the hippocampus, which is a valuable addition to our mechanistic understanding of the learning and memory functions of the marginal division of the striatum.
P 物质是一种内源性神经激肽，存在于中枢和外周神经系统中。神经肽 P 物质及其高亲和力受体神经激肽 1 受体已被证实在中枢神经系统的炎症、血压、运动行为和焦虑中发挥着重要作用。P 物质在海马体和纹状体边缘区对记忆的影响仍知之甚少。与海马体作为对照相比，免疫荧光显示正常大鼠纹状体边缘区 P 物质受体神经激肽 1 的表达水平较高。在大鼠海马体或纹状体边缘区单侧或双侧注射神经激肽 1 受体 mRNA 的反义寡核苷酸，可有效降低神经激肽 1 受体的表达。无论注射部位如何，接受这种反义寡核苷酸的大鼠在 Y 迷宫测试中明显增加了电击次数。这些结果表明，纹状体边缘区在学习和记忆方面发挥着类似于海马体的功能，这为我们深入了解纹状体边缘区的学习和记忆功能提供了有价值的补充。
