Shon Minsu, Shanmugavel Ramachandran, Shin Giyoung, Mathew Sam, Lee Sang-Hyeup, Yun Hyungdon
School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, South Korea.
Chem Commun (Camb). 2014 Oct 28;50(84):12680-3. doi: 10.1039/c3cc44864a.
In this study, we successfully synthesized enantiomerically pure (R)- and (S)-γ-amino acids (>99% ee) using ω-transaminase (ω-TA) through kinetic resolution and asymmetric synthesis respectively. The present study demonstrates the high potentiality of ω-TA reaction for the production of chiral γ-amino acids.
在本研究中，我们分别通过动力学拆分和不对称合成，利用ω-转氨酶（ω-TA）成功合成了对映体纯的（R）-和（S）-γ-氨基酸（对映体过量>99%）。本研究证明了ω-TA反应在生产手性γ-氨基酸方面具有很高的潜力。
