通过¹¹C-乙酸PET定量心肌血流量的改进溢出校正模型：与¹⁵O-H₂O PET的比较

Improved spillover correction model to quantify myocardial blood flow by 11C-acetate PET: comparison with 15O-H 2O PET.

作者信息

Mori Yuki, Manabe Osamu, Naya Masanao, Tomiyama Yuuki, Yoshinaga Keiichiro, Magota Keiichi, Oyama-Manabe Noriko, Hirata Kenji, Tsutsui Hiroyuki, Tamaki Nagara, Katoh Chietsugu

机构信息

Faculty of Health Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

出版信息

Ann Nucl Med. 2015 Jan;29(1):15-20. doi: 10.1007/s12149-014-0904-z. Epub 2014 Sep 11.

DOI:10.1007/s12149-014-0904-z

PMID:25209232

Abstract

OBJECTIVE

(11)C-acetate has been applied for evaluation of myocardial oxidative metabolism and can simultaneously estimate myocardial blood flow (MBF). We developed a new method using two-parameter spillover correction to estimate regional MBF (rMBF) with (11)C-acetate PET in reference to MBF derived from (15)O-H2O PET. The usefulness of our new approach was evaluated compared to the conventional method using one-parameter spillover correction.

METHODS

Sixty-three subjects were examined with (11)C-acetate and (15)O-H2O dynamic PET at rest. Inflow rate of (11)C-acetate (K1) was compared with MBF derived from (15)O-H2O PET. For the derivation, the relationship between K1 and MBF from (15)O-H2O was linked by the Renkin-Crone model in 20 subjects as a pilot group. One-parameter and two-parameter corrections were applied to suppress the spillover between left ventricular (LV) wall and LV cavity. Validation was set using the other 43 subjects' data. Finally, rMBFs were calculated using relational expression derived from the pilot-group data.

RESULTS

The relationship between K1 and MBF derived from (15)O-H2O PET was approximated as K1 = [1-0.764 × exp(-1.001/MBF)] MBF from the pilot data using the two-parameter method. In the validation set, the correlation coefficient between rMBF from (11)C-acetate and (15)O-H2O demonstrated a significantly higher relationship with the two-parameter spillover correction method than the one-parameter spillover correction method (r = 0.730, 0.592, respectively, p < 0.05).

CONCLUSION

In (11)C-acetate PET study, the new two-parameter spillover correction method dedicated more accurate and robust myocardial blood flow than the conventional one-parameter method.

摘要

目的

（11）C-乙酸盐已被用于评估心肌氧化代谢，并可同时估计心肌血流量（MBF）。我们开发了一种新方法，使用双参数溢出校正，通过（11）C-乙酸盐PET参照源自（15）O-H2O PET的MBF来估计局部心肌血流量（rMBF）。与使用单参数溢出校正的传统方法相比，我们评估了这种新方法的有效性。

方法

63名受试者在静息状态下接受了（11）C-乙酸盐和（15）O-H2O动态PET检查。将（11）C-乙酸盐的流入率（K1）与源自（15）O-H2O PET的MBF进行比较。为了进行推导，在作为试验组的20名受试者中，通过Renkin-Crone模型将K1与源自（15）O-H2O的MBF之间的关系联系起来。应用单参数和双参数校正来抑制左心室（LV）壁与LV腔之间的溢出。使用其他43名受试者的数据进行验证。最后，使用从试验组数据得出的关系式计算rMBF。

结果

使用双参数方法从试验数据中得出，（11）C-乙酸盐的K1与源自（15）O-H2O PET的MBF之间的关系近似为K1 = [1 - 0.764×exp（-1.001/MBF）]MBF。在验证组中，与单参数溢出校正方法相比，（11）C-乙酸盐的rMBF与（15）O-H2O之间的相关系数在双参数溢出校正方法下显示出显著更高的相关性（分别为r = 0.730、0.592，p < 0.05）。