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双膦酸盐（伊班膦酸钠）给药阻碍兔磨牙移动：一项影像学评估。

Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment.

作者信息

Venkataramana V, Kumar S Sathesh, Reddy B Vishnuvardhan, Cherukuri A Sreekanth, Sigamani K Raja, Chandrasekhar G

机构信息

Department of Orthodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences, Dilshuknagar, Hyderabad, Andhra Pradesh, India.

Department of Orthodontics, JKKN Dental College, Komarapalyam, Namakkal, Tamilnadu, India.

出版信息

J Pharm Bioallied Sci. 2014 Jul;6(Suppl 1):S165-70. doi: 10.4103/0975-7406.137440.

DOI:10.4103/0975-7406.137440
PMID:25210364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4157260/
Abstract

INTRODUCTION

Bisphosphonate (Bp)-ibandronate is a pharmacological agent, exhibits antiosteoclastic or antiresorptive activity and used to treat osteolytic or osteopenic disorders. BP-ibandronate may also interfere during orthodontic tooth movement. The aim of this study was to examine the influence of locally administered Bp-ibandronate on experimental tooth movement in rabbits.

MATERIALS AND METHODS

Twenty rabbits were divided into two groups- "10" served as Group-1 (control) and other "10" as Group-2 (experimental). Both groups received nickel-titanium closed coil springs with 100 g force between mandibular molar and incisors. Group-1 animals received 1 ml normal saline and Group-2 animals received ibandronate solution (0.3 mg/kg body weight) locally, mesial to the mandibular molar on the 1(st), 7(th), and 14(th) day of the experiment. A total of "40" lateral cephalograms were taken from both groups on the 1(st) and 21(st) day using a digital X-ray unit (Siemens X-ray systems, 300 mA Pleomophos analog, 2008, Germany). Individually, each animal's radiograph was traced manually and superimposed. The molar tooth movement was measured with the help of a standard metric scale.

RESULTS

The Student's t-test has been done to compare the mean values of Group-1 (4.650 ± 0.363) and Group-2 (2.030 ± 0.291) and the difference was statistically significant (P < 0.001).

CONCLUSION

The retarded molar tooth movement was noticed in local drug administered rabbits, which could be beneficial in orthodontics to control the undesired tooth movement.

摘要

引言

双膦酸盐（Bp）-伊班膦酸钠是一种药理制剂，具有抗破骨细胞或抗吸收活性，用于治疗溶骨性或骨质减少性疾病。BP-伊班膦酸钠在正畸牙齿移动过程中也可能产生干扰。本研究的目的是探讨局部应用Bp-伊班膦酸钠对兔实验性牙齿移动的影响。

材料与方法

将20只兔分为两组，10只为第1组（对照组），另外10只为第2组（实验组）。两组均在下颌磨牙与切牙之间施加100 g力的镍钛闭合螺旋弹簧。第1组动物接受1 ml生理盐水，第2组动物在实验的第1、7和14天在下颌磨牙近中局部接受伊班膦酸钠溶液（0.3 mg/kg体重）。使用数字X射线装置（西门子X射线系统，300 mA Pleomophos模拟机，2008年，德国）在第1天和第21天从两组共获取40张侧位头影测量片。分别对每只动物的X线片进行手工描绘并叠加。借助标准度量尺测量磨牙的牙齿移动情况。

结果

采用学生t检验比较第1组（4.650±0.363）和第2组（2.030±0.291）的平均值，差异具有统计学意义（P<0.001）。

结论

在局部用药的兔中观察到磨牙牙齿移动延迟，这在正畸治疗中可能有助于控制不必要的牙齿移动。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/d7ebeae39763/JPBS-6-165-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/f90502be9c8b/JPBS-6-165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/86310b7cfbd8/JPBS-6-165-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/b7c4409e5913/JPBS-6-165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/eb0325d87e9a/JPBS-6-165-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/5309ed18e9a7/JPBS-6-165-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/f125e857060f/JPBS-6-165-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/d7ebeae39763/JPBS-6-165-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/f90502be9c8b/JPBS-6-165-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/86310b7cfbd8/JPBS-6-165-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/b7c4409e5913/JPBS-6-165-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/eb0325d87e9a/JPBS-6-165-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/5309ed18e9a7/JPBS-6-165-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/f125e857060f/JPBS-6-165-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4070/4157260/d7ebeae39763/JPBS-6-165-g009.jpg

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