Arias Oscar R, Marquez-Orozco Maria C
Department of Orthodontics, Universidad Intercontinental, México DF, Mexico.
Am J Orthod Dentofacial Orthop. 2006 Sep;130(3):364-70. doi: 10.1016/j.ajodo.2004.12.027.
Orthodontic patients often take analgesics for pain during treatment. But various analgesics have different capacities to inhibit prostaglandins, and these differences might affect tooth movement. The purposes of this study were to determine by direct measurement the effects that acetylsalicylic acid, ibuprofen, and acetaminophen have on orthodontic tooth movement in rats and to evaluate histologically the differences in bone resorption in the pressure area in rats treated with these analgesics.
Thirty-six adult male Wistar rats were divided in 4 groups of 9 each. Orthodontic appliances were placed on the rats' incisors. In the 3 experimental groups, analgesics were diluted in reverse osmosis water and delivered via a gastric tube: 100 mg/kg acetylsalicylic acid, or 30 mg/kg ibuprofen, or 200 mg/kg acetaminophen. Control animals received only the reverse osmosis water. At the end of the experimental period, the rats were killed and histological examinations were performed.
Analysis of variance showed statistically significant differences between the control group, which was given reverse osmosis water, and the groups given aspirin and ibuprofen. There were also statistically significant differences between the acetaminophen group and the ibuprofen and aspirin groups, respectively. There was no significant difference between the acetaminophen group and the control group, or between the aspirin and ibuprofen groups. Tooth movement was similar in the groups.
The results indicate that nonsteroidal anti-inflammatory analgesics such as aspirin and ibuprofen diminish the number of osteoclasts, probably by inhibiting the secretion of prostaglandins, thereby reducing orthodontic tooth movement. Acetaminophen did not affect orthodontic tooth movement in rats, and it might be the analgesic of choice for treating pain associated with orthodontic treatment.
正畸患者在治疗期间常服用镇痛药来缓解疼痛。但不同的镇痛药抑制前列腺素的能力不同，而这些差异可能会影响牙齿移动。本研究的目的是通过直接测量来确定乙酰水杨酸、布洛芬和对乙酰氨基酚对大鼠正畸牙齿移动的影响，并从组织学角度评估用这些镇痛药治疗的大鼠压力区骨吸收的差异。
将36只成年雄性Wistar大鼠分为4组，每组9只。在大鼠的切牙上放置正畸矫治器。在3个实验组中，将镇痛药溶解于反渗透水中，通过胃管给药：100mg/kg乙酰水杨酸、30mg/kg布洛芬或200mg/kg对乙酰氨基酚。对照组动物仅给予反渗透水。实验期结束时，处死大鼠并进行组织学检查。
方差分析显示，给予反渗透水的对照组与给予阿司匹林和布洛芬的组之间存在统计学显著差异。对乙酰氨基酚组与布洛芬组和阿司匹林组之间也分别存在统计学显著差异。对乙酰氨基酚组与对照组之间，以及阿司匹林组和布洛芬组之间均无显著差异。各组的牙齿移动情况相似。
结果表明，阿司匹林和布洛芬等非甾体抗炎镇痛药可能通过抑制前列腺素的分泌减少破骨细胞数量，从而减少正畸牙齿移动。对乙酰氨基酚对大鼠正畸牙齿移动无影响，可能是治疗正畸相关疼痛的首选镇痛药。
