Guan Ling, Lin Suai, Yan Weijun, Chen Lei, Wang Xiaofeng
a Department of Orthodontics , First Affiliated Hospital, Harbin Medical University , Harbin , P.R. China.
b Department of Oral and Maxillofacial Surgery , Second Affiliated Hospital Harbin Medical University , Harbin , P.R. China.
Acta Odontol Scand. 2017 Nov;75(8):595-602. doi: 10.1080/00016357.2017.1365375. Epub 2017 Aug 17.
Our main aim was to evaluate the effects of calcitonin (CT) on orthodontic tooth movement (OTM) and orthodontic root resorption in a rat model.
Eighty male Wistar rats were randomly divided into five groups. Rats in the negative control group were not given any appliances or injections. All the remaining rats were used to establish a model of OTM. The positive control group were then injected with normal saline, while rats in the three experimental groups were injected with 0.2 IU, 1 IU or 5 IU/kg/day CT. Nickel-titanium closed-coil springs were used to deliver an initial 50 g mesial force to the left maxillary first molar for 14 days in rats in the positive control group and the experimental groups. Each group was randomly subdivided into two groups, one for analysis of tooth movement, tissue changes and tartrate-resistant acid phosphatase (TRAP)-positive cells in alveolar bone, the other to examine root resorption by scanning electron microscopy.
The OTM distance, the number of force-induced osteoclasts and root resorption areas were significantly decreased in CT-injected rats in a dose-dependent manner.
Administration of CT reduces the root resorption area and may therefore be effective as a novel adjunctive orthodontic approach to diminish undesired tooth movement via enhancing anchorage or preventing relapse after OTM.
我们的主要目的是在大鼠模型中评估降钙素（CT）对正畸牙齿移动（OTM）和正畸牙根吸收的影响。
80只雄性Wistar大鼠随机分为五组。阴性对照组大鼠未给予任何矫治器或注射。其余所有大鼠用于建立OTM模型。阳性对照组注射生理盐水，而三个实验组大鼠分别注射0.2 IU、1 IU或5 IU/kg/天的CT。在阳性对照组和实验组大鼠中，使用镍钛闭合线圈弹簧向左侧上颌第一磨牙施加初始50 g近中力，持续14天。每组随机再分为两组，一组用于分析牙齿移动、组织变化以及牙槽骨中抗酒石酸酸性磷酸酶（TRAP）阳性细胞，另一组通过扫描电子显微镜检查牙根吸收情况。
注射CT的大鼠的OTM距离、力诱导破骨细胞数量和牙根吸收面积均呈剂量依赖性显著降低。
给予CT可减少牙根吸收面积，因此作为一种新型辅助正畸方法，通过增强支抗或防止OTM后复发来减少不必要的牙齿移动可能是有效的。
