Aiman Umme, Najmi Ahmad, Khan Rahat Ali
Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Department of Pharmacology, Index Medical College, Indore, Madhya Pradesh, India.
J Pharmacol Pharmacother. 2014 Jul;5(3):181-5. doi: 10.4103/0976-500X.136097.
Statins are one of the most commonly used drugs in the world based on their potential to prevent adverse cardiovascular events. These cholesterol-lowering drugs received a US Food and Drug Administration warning, in February 2012, regarding increased risk of incident diabetes and impaired glycemic control in patients who already have diabetes. The possible association of diabetes with statin therapy has started a wave of discussion in the medical community. A number of meta-analyses conducted in recent years have demonstrated that the association is real although causality has not been proved yet. Individual statins differ with respect to their diabetogenic property; women and elderly persons appear to be at increased risk. Various aspects of statin's adverse effect on glycemic control remain to be explored. As further research in this area continues, physicians might still take some precautions to make risk benefit ratio more favorable for the patients.
基于他汀类药物预防心血管不良事件的潜力，它们是世界上最常用的药物之一。这些降胆固醇药物在2012年2月收到了美国食品药品监督管理局的警告，提示已有糖尿病的患者发生糖尿病的风险增加以及血糖控制受损。糖尿病与他汀类药物治疗之间可能存在的关联引发了医学界的一轮讨论。近年来进行的多项荟萃分析表明，这种关联是真实存在的，尽管因果关系尚未得到证实。不同的他汀类药物在致糖尿病特性方面存在差异；女性和老年人似乎风险更高。他汀类药物对血糖控制的不良影响的各个方面仍有待探索。随着该领域进一步研究的继续，医生仍可能采取一些预防措施，以使患者的风险效益比更有利。
