Kim Kyung-Joo, Kang Nam E, Oh Yoon Sin, Jang Se-Eun
Department of Food and Nutrition, Eulji University, 553, Sanseong-daero, Seongnam, Gyeonggi-do 13135, Republic of Korea.
Biochem Res Int. 2023 Jun 21;2023:8488648. doi: 10.1155/2023/8488648. eCollection 2023.
(family ) is a natural product broadly used as an antioxidative, hepatoprotective, antibacterial, and anti-inflammatory agent in East Asia. In the present study, eupatilin, the main constituent of , was investigated as an antihyperlipidemic agent. Eupatilin inhibited 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase (HCR), an enzyme that is a therapeutic target for hyperlipidemia, in an assay using rat liver. In addition, oral administration of eupatilin significantly lowered the serum levels of total cholesterol (TC) and triglycerides (TG) in corn oil-induced and Triton WR-1339-induced hyperlipidemic mice. These results suggest that eupatilin can alleviate hyperlipidemia by inhibiting HCR.
（某物质）在东亚地区是一种广泛用作抗氧化、保肝、抗菌和抗炎剂的天然产物。在本研究中，对该物质的主要成分灯盏乙素作为抗高血脂剂进行了研究。在使用大鼠肝脏的实验中，灯盏乙素抑制了3-羟基-3-甲基戊二酰辅酶A（HMG）还原酶（HCR），该酶是高血脂症的治疗靶点。此外，口服灯盏乙素可显著降低玉米油诱导和Triton WR-1339诱导的高血脂小鼠的血清总胆固醇（TC）和甘油三酯（TG）水平。这些结果表明灯盏乙素可通过抑制HCR来缓解高血脂症。
