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病例报告：外用他克莫司成功治疗孤立性肥大细胞瘤。

Case Report: Solitary mastocytoma treated successfully with topical tacrolimus.

作者信息

Sukesh M S, Dandale Ameet, Dhurat Rachita, Sarkate Ankur, Ghate Smita

机构信息

Dermatology Department, LTM Medical College and General Hospital, Sion, Mumbai, 400022, India.

出版信息

F1000Res. 2014 Aug 1;3:181. doi: 10.12688/f1000research.3253.1. eCollection 2014.

DOI:10.12688/f1000research.3253.1
PMID:25210620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4156028/
Abstract

Solitary mastocytoma, a rare dermatological entity accounts for 10-15% of cutaneous mastocytosis. We report a rare case of solitary mastocytoma presenting at birth, treated successfully with topical tacrolimus. Along with reassurance and strict avoidance of triggering factors, no recurrence was reported within the one year follow-up period.

摘要

孤立性肥大细胞瘤是一种罕见的皮肤病学实体，占皮肤肥大细胞增多症的10% - 15%。我们报告了一例罕见的出生时即出现的孤立性肥大细胞瘤病例，经外用他克莫司成功治疗。除了给予患者安慰并严格避免触发因素外，在一年的随访期内未报告复发情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0617/4156028/6823166927a8/f1000research-3-3493-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0617/4156028/30233a022938/f1000research-3-3493-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0617/4156028/3336033789a3/f1000research-3-3493-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0617/4156028/f28c8df9822c/f1000research-3-3493-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0617/4156028/6823166927a8/f1000research-3-3493-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0617/4156028/30233a022938/f1000research-3-3493-g0000.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0617/4156028/3336033789a3/f1000research-3-3493-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0617/4156028/f28c8df9822c/f1000research-3-3493-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0617/4156028/6823166927a8/f1000research-3-3493-g0003.jpg

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本文引用的文献

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Pimecrolimus, a topical calcineurin inhibitor used in the treatment of atopic eczema.吡美莫司，一种局部用钙调磷酸酶抑制剂，用于治疗特应性皮炎。
Expert Opin Drug Metab Toxicol. 2013 Nov;9(11):1507-16. doi: 10.1517/17425255.2013.819343. Epub 2013 Jul 22.
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Toluidine blue: A review of its chemistry and clinical utility.甲苯胺蓝：其化学性质与临床应用综述
J Oral Maxillofac Pathol. 2012 May;16(2):251-5. doi: 10.4103/0973-029X.99081.
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Mastocytosis in children: a protocol for management.儿童肥大细胞增多症：管理方案
Pediatr Dermatol. 2008 Jul-Aug;25(4):493-500. doi: 10.1111/j.1525-1470.2008.00738.x.
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Adult onset, hypopigmented solitary mastocytoma: report of two cases.成人起病的色素减退性孤立性肥大细胞瘤：两例报告
Indian J Dermatol Venereol Leprol. 2008 Jan-Feb;74(1):41-3. doi: 10.4103/0378-6323.38407.
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[Cutaneous mastocytosis].[皮肤肥大细胞增多症]
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Cutaneous mastocytosis: demographic aspects and clinical features of 55 patients.皮肤肥大细胞增多症：55例患者的人口统计学特征和临床特点
J Eur Acad Dermatol Venereol. 2006 Sep;20(8):969-73. doi: 10.1111/j.1468-3083.2006.01696.x.
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A red-brown plaque on the nape. Solitary mastocytoma.
Arch Dermatol. 2004 Oct;140(10):1275-80. doi: 10.1001/archderm.140.10.1275-e.
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Tacrolimus and pimecrolimus: from clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis.他克莫司和吡美莫司：从聪明的原核生物到抑制钙调神经磷酸酶及治疗特应性皮炎
J Am Acad Dermatol. 2002 Feb;46(2):228-41. doi: 10.1067/mjd.2002.120942.