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Supravital staining: It's role in detecting early malignancies.体外活体染色：其在早期恶性肿瘤检测中的作用
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Utility of toluidine blue staining and brush biopsy in precancerous and cancerous oral lesions.甲苯胺蓝染色和刷检在口腔癌前病变和癌性病变中的应用。
Acta Cytol. 2007 Sep-Oct;51(5):788-94. doi: 10.1159/000325843.
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Critical evaluation of diagnostic aids for the detection of oral cancer.口腔癌检测诊断辅助手段的批判性评估。
Oral Oncol. 2008 Jan;44(1):10-22. doi: 10.1016/j.oraloncology.2007.06.011. Epub 2007 Sep 6.
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Toluidine blue uptake in potentially malignant oral lesions in vivo: clinical and histological assessment.体内潜在恶性口腔病变中甲苯胺蓝摄取情况：临床与组织学评估
Oral Oncol. 2006 Jan;42(1):89-95. doi: 10.1016/j.oraloncology.2005.06.016. Epub 2005 Oct 25.
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Reliability of toluidine blue application in the detection of oral epithelial dysplasia and in situ and invasive squamous cell carcinomas.甲苯胺蓝应用于检测口腔上皮发育异常及原位和浸润性鳞状细胞癌的可靠性。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 May;91(5):535-40. doi: 10.1067/moe.2001.112949.
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The application of toluidine blue as a diagnostic adjunct in the detection of epithelial dysplasia.甲苯胺蓝作为诊断辅助手段在上皮发育异常检测中的应用。
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The utility of toluidine blue application as a diagnostic aid in patients previously treated for upper oropharyngeal carcinoma.甲苯胺蓝应用作为曾接受过上咽癌治疗患者的诊断辅助手段的效用。
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Sensitivity and specificity of OraScan (R) toluidine blue mouthrinse in the detection of oral cancer and precancer.OraScan（R）甲苯胺蓝漱口水在口腔癌及癌前病变检测中的敏感性和特异性
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甲苯胺蓝：其化学性质与临床应用综述

Toluidine blue: A review of its chemistry and clinical utility.

作者信息

Sridharan Gokul, Shankar Akhil A

机构信息

Department of Oral Pathology and Microbiology, YMT Dental College and Hospital, Kharghar, Navi Mumbai, Maharashtra, India.

出版信息

J Oral Maxillofac Pathol. 2012 May;16(2):251-5. doi: 10.4103/0973-029X.99081.

DOI:10.4103/0973-029X.99081
PMID:22923899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3424943/
Abstract

Toluidine blue is a basic thiazine metachromatic dye with high affinity for acidic tissue components, thereby staining tissues rich in DNA and RNA. It has found wide applications both as vital staining in living tissues and as a special stain owing to its metachromatic property. Toluidine blue has been used in vivo to identify dysplasia and carcinoma of the oral cavity. Use of toluidine blue in tissue sections is done with the aim to highlight components, such as mast cells granules, mucins, and cartilage. This article provides an overview on chemistry, technique, and the various applications of toluidine blue.

摘要

甲苯胺蓝是一种碱性噻嗪异染性染料，对酸性组织成分具有高亲和力，因此可对富含DNA和RNA的组织进行染色。由于其异染特性，它在活体组织的活体染色以及特殊染色方面都有广泛应用。甲苯胺蓝已被用于体内识别口腔发育异常和癌。在组织切片中使用甲苯胺蓝的目的是突出显示诸如肥大细胞颗粒、粘蛋白和软骨等成分。本文概述了甲苯胺蓝的化学性质、技术及各种应用。