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Ovarian cyst formation: a complication of gonadotropin-releasing hormone agonist therapy.

作者信息

Feldberg D, Ashkenazi J, Dicker D, Yeshaya A, Goldman G A, Dicker D, Goldman J A

机构信息

Sherman Institute of Fertility, Golda Meir Medical Center (Hasharon Hospital), Petah-Tikva, Israel.

出版信息

Fertil Steril. 1989 Jan;51(1):42-5. doi: 10.1016/s0015-0282(16)60425-9.

DOI:10.1016/s0015-0282(16)60425-9
PMID:2521325
Abstract

Since gonadotropin-releasing hormone (GnRH) analogs were introduced into clinical therapeutic use, several side effects directly related to the hypoestrogenic state have been reported. The authors have encountered a rather infrequent complication, namely ovarian cystic formations, when using these compounds for selected in vitro fertilization and embryo transfer (IVF-ET) cases. In 7 of 24 patients with Decapeptyl (D-Trp6-luteinizing hormone-releasing hormone [LH-RH], Ferring, Kiel, FRG) treatment, and in 5 of 22 patients treated with Buserelin (Superfact, Hoechst A.G., Frankfurt, FRG), solitary ovarian cysts developed during the down-regulation phase. Their growth did not change during ovulation induction with menotropins. Although the mechanism of ovarian cyst formation during GnRH agonist treatment is not clear, their presence does not appear to interfere with the fertility of these women.

摘要

相似文献

1
Ovarian cyst formation: a complication of gonadotropin-releasing hormone agonist therapy.
Fertil Steril. 1989 Jan;51(1):42-5. doi: 10.1016/s0015-0282(16)60425-9.
2
[Increased incidence of ovarian hyperstimulation syndrome following combined GnRH agonist/hMG therapy].
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3
Pretreatment with an oral contraceptive is effective in reducing the incidence of functional ovarian cyst formation during pituitary suppression by gonadotropin-releasing hormone analogues.在使用促性腺激素释放激素类似物抑制垂体期间，口服避孕药预处理可有效降低功能性卵巢囊肿形成的发生率。
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4
Effects of pretreatment with an oral contraceptive on the time required to achieve pituitary suppression with gonadotropin-releasing hormone analogues and on subsequent implantation and pregnancy rates.口服避孕药预处理对使用促性腺激素释放激素类似物实现垂体抑制所需时间以及随后的着床率和妊娠率的影响。
Fertil Steril. 1998 Dec;70(6):1063-9. doi: 10.1016/s0015-0282(98)00333-1.
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Comparison between flare up and down regulation effects of luteinizing hormone-releasing hormone agonists in an in vitro fertilization program.体外受精程序中促黄体生成素释放激素激动剂的 flare up 与下调作用之间的比较。 （注：“flare up”在医学领域可能有特定含义，具体需结合上下文准确理解，这里直接保留英文表述是因为不太明确其在该语境下的精准中文术语。）
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Results of in vitro fertilization and embryo transfer by combined long-acting gonadotropin-releasing hormone analog D-Trp-6-luteinizing hormone-releasing hormone and gonadotropins.长效促性腺激素释放激素类似物D-色氨酸-6-促黄体生成素释放激素与促性腺激素联合用于体外受精和胚胎移植的结果
Fertil Steril. 1989 Jan;51(1):95-9. doi: 10.1016/s0015-0282(16)60435-1.
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The use of long-acting gonadotropin-releasing hormone agonist (GnRH-a; decapeptyl) and gonadotropins versus short-acting GnRH-a (buserelin) and gonadotropins before and during ovarian stimulation for in vitro fertilization (IVF).在体外受精（IVF）的卵巢刺激之前及期间，长效促性腺激素释放激素激动剂（GnRH-a；曲普瑞林）与促性腺激素联用，对比短效GnRH-a（布舍瑞林）与促性腺激素联用的情况。
J In Vitro Fert Embryo Transf. 1991 Oct;8(5):254-9. doi: 10.1007/BF01139780.
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IVF-ET in women with refractory polycystic ovarian disease.难治性多囊卵巢疾病女性的体外受精-胚胎移植
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9
Short-term utilization of a gonadotropin-releasing hormone agonist (buserelin) for induction of ovulation in an in vitro fertilization program.在体外受精程序中短期使用促性腺激素释放激素激动剂（布舍瑞林）诱导排卵。
Ann N Y Acad Sci. 1988;541:96-102. doi: 10.1111/j.1749-6632.1988.tb22245.x.
10
Prospective, randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (cetrorelix) or a depot formula of an LH-RH agonist (triptorelin).一项关于体外受精-胚胎移植的前瞻性、随机、对照研究，比较单次剂量的促黄体生成素释放激素（LH-RH）拮抗剂（西曲瑞克）或LH-RH激动剂长效制剂（曲普瑞林）的效果。
Fertil Steril. 2000 Feb;73(2):314-20. doi: 10.1016/s0015-0282(99)00524-5.

引用本文的文献

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HCG Trigger of GnRH Agonist-Induced Functional Ovarian Cysts Does Not Decrease Clinical Pregnancy Rate in GnRHa Pretreated Frozen Cycles: Evidence From a Retrospective Cohort Study.HCG 扳机不会降低 GnRH 激动剂预处理冻融周期的临床妊娠率：一项回顾性队列研究的证据。
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2
Functional Ovarian Cysts in Artificial Frozen-Thawed Embryo Transfer Cycles With Depot Gonadotropin-Releasing Hormone Agonist.冻融胚胎移植周期中使用长效促性腺激素释放激素激动剂的功能性卵巢囊肿。
Front Endocrinol (Lausanne). 2022 Apr 29;13:828993. doi: 10.3389/fendo.2022.828993. eCollection 2022.
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Prolonged pituitary down-regulation with full-dose of gonadotropin-releasing hormone agonist in different menstrual cycles: a retrospective cohort study.
不同月经周期中使用全剂量促性腺激素释放激素激动剂进行长期垂体降调节：一项回顾性队列研究
PeerJ. 2019 Apr 29;7:e6837. doi: 10.7717/peerj.6837. eCollection 2019.
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Ovarian Cyst Formation Following Gonadotropin-Releasing Hormone-Agonist Administration Decreases the Oocyte Quality in IVF Cycles.促性腺激素释放激素激动剂治疗后形成的卵巢囊肿会降低 IVF 周期中的卵母细胞质量。
Balkan Med J. 2012 Jun;29(2):197-200. doi: 10.5152/balkanmedj.2011.019. Epub 2012 Jun 1.
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J Assist Reprod Genet. 2000 May;17(5):260-3. doi: 10.1023/a:1009406315729.
7
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8
Comparison of ovarian stimulation regimens for in vitro fertilization (IVE) with and without a gonadotropin-releasing hormone (GnRH) agonist: results of a randomized study.
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