Ashkenazi J, Feldberg D, Dicker D, Yeshaya A, Ayalon D, Goldman J A
Sherman Fertility Institute, Golda Meir Medical Center (Hasharon Hospital), Petah Tikva, Israel.
Eur J Obstet Gynecol Reprod Biol. 1989 Feb;30(2):157-61. doi: 10.1016/0028-2243(89)90063-4.
Polycystic ovarian disease may be a cause of hormonal infertility. This condition is often refractory to therapy. Three groups of randomly chosen women with refractory polycystic ovarian disease (PCOD) were treated by induction of ovulation with pFSH/hCG, pFSH/hMG/hCG or after down-regulation of the ovaries with a GnRH analogue (Decapeptyl). Out of 18 patients six conceived in the first in vitro fertilization-embryo transfer (IVF-ET) cycle, and two further women conceived in a later cycle. It is suggested that patients with refractory PCOD should be referred for IVF-ET therapy, possibly after treatment with a GnRH analogue.
多囊卵巢疾病可能是激素性不孕的一个原因。这种病症通常对治疗有抗性。三组随机选取的患有难治性多囊卵巢疾病（PCOD）的女性，分别接受了促卵泡生成素/人绒毛膜促性腺激素（pFSH/hCG）、促卵泡生成素/人绝经期促性腺激素/人绒毛膜促性腺激素（pFSH/hMG/hCG）诱导排卵治疗，或者在使用促性腺激素释放激素类似物（曲普瑞林）使卵巢降调节后进行治疗。18名患者中有6名在首个体外受精-胚胎移植（IVF-ET）周期受孕，另有两名女性在之后的周期受孕。建议难治性PCOD患者在可能接受促性腺激素释放激素类似物治疗后，转诊接受IVF-ET治疗。
