Caspi E, Ron-El R, Golan A, Nachum H, Herman A, Soffer Y, Weinraub Z
Assaf Harofe Medical Centre, Zerifin, Israel.
Fertil Steril. 1989 Jan;51(1):95-9. doi: 10.1016/s0015-0282(16)60435-1.
To avoid cancellation of in vitro fertilization (IVF) because of early luteinization, pituitary suppression by gonadotropin-releasing hormone (GnRH) was carried out in 111 cycles. D-Trp-6-luteinizing hormone-releasing hormone (LH-RH) microcapsules were administered intramuscularly at menstruation and menotropin (hMG) stimulation was started 19 days (mean) later. In 3 cycles (2.7%), only early luteinization occurred. The mean number of oocytes per cycle was 6.7, with a fertilization and cleavage rate of 50 and 95%, respectively. A mean of 3.4 embryos were transferred per cycle. The 111 cycles resulted in 34 clinical pregnancies, 41% per cycle with embryo transfer. The early abortion, multiple pregnancy, and ovarian hyperstimulation rates were 24, 18, and 11%, respectively. It is concluded that D-Trp-6-LH-RH/hMG cycles are associated with a very low occurrence of early luteinization, high number of oocytes and embryos, and a substantial incidence of ovarian hyperstimulation syndrome.
为避免因过早黄素化而取消体外受精（IVF），对111个周期进行了促性腺激素释放激素（GnRH）垂体抑制。在月经时肌肉注射D-色氨酸-6-促黄体生成素释放激素（LH-RH）微胶囊，19天（平均）后开始用人绝经期促性腺激素（hMG）刺激。在3个周期（2.7%）中，仅发生了过早黄素化。每个周期卵母细胞的平均数为6.7个，受精率和分裂率分别为50%和95%。每个周期平均移植3.4个胚胎。111个周期中有34例临床妊娠，胚胎移植周期的妊娠率为41%。早期流产率、多胎妊娠率和卵巢过度刺激综合征发生率分别为24%、18%和11%。结论是，D-色氨酸-6-LH-RH/hMG周期过早黄素化发生率极低，卵母细胞和胚胎数量多，卵巢过度刺激综合征发生率高。
