Yasue H, Obata K, Okumura K, Kurose M, Ogawa H, Matsuyama K, Jougasaki M, Saito Y, Nakao K, Imura H
Division of Cardiology, Kumamoto University Medical School, Japan.
J Clin Invest. 1989 Jan;83(1):46-51. doi: 10.1172/JCI113883.
To examine whether atrial natriuretic polypeptide (ANP) is released from the left ventricle in patients with dilated cardiomyopathy (DCM) we measured plasma ANP level in the aortic root (Ao), the anterior interventricular vein (AIV), the great cardiac vein (GCV), and the coronary sinus (CS) in 11 patients with DCM and 18 control subjects. Plasma ANP levels in Ao, AIV, GCV, and CS were 454 +/- 360, 915 +/- 584, 1,308 +/- 926, and 1,884 +/- 1,194 pg/ml, respectively, in the patients with DCM and 108 +/- 42, 127 +/- 55, 461 +/- 224, and 682 +/- 341 pg/ml, respectively, in the control subjects. There was no significant difference in the plasma ANP levels between Ao and AIV in the control subjects. On the contrary, there was a significant (P less than 0.001) step-up in plasma ANP levels between Ao and AIV in patients with DCM. Thus, the difference in ANP levels between Ao and AIV was significantly increased in patients with DCM as compared with the control subjects (461 +/- 248 vs. 19 +/- 59 pg/ml, P less than 0.001). The difference in ANP levels between Ao and CS was also significantly increased in patients with DCM as compared with the control subjects (1,429 +/- 890 vs. 577 +/- 318 pg/ml, P less than 0.001). We conclude that ANP is released in increased amounts into the circulation from the left ventricle as well as from the heart as a whole in patients with DCM.
为了研究扩张型心肌病（DCM）患者左心室是否释放心房利钠多肽（ANP），我们测量了11例DCM患者和18例对照者主动脉根部（Ao）、前室间静脉（AIV）、大心静脉（GCV）及冠状窦（CS）的血浆ANP水平。DCM患者的Ao、AIV、GCV及CS血浆ANP水平分别为454±360、915±584、1308±926及1884±1194 pg/ml，对照者分别为108±42、127±55、461±224及682±341 pg/ml。对照者中Ao与AIV的血浆ANP水平无显著差异。相反，DCM患者中Ao与AIV的血浆ANP水平有显著升高（P＜0.001）。因此，与对照者相比，DCM患者中Ao与AIV的ANP水平差异显著增大（461±248 vs. 19±59 pg/ml，P＜0.001）。与对照者相比，DCM患者中Ao与CS的ANP水平差异也显著增大（1429±890 vs. 577±318 pg/ml，P＜0.001）。我们得出结论，DCM患者中，ANP从左心室以及整个心脏释放进入循环的量增加。
