Saari J T
U.S. Department of Agriculture, Grand Forks Human Nutrition Research Center, North Dakota 58202.
Proc Soc Exp Biol Med. 1989 Jan;190(1):121-4. doi: 10.3181/00379727-190-1-rc1.
Published reports indicate that Cu deficiency reduces antioxidant defenses and may result in tissue peroxidation. Dimethyl sulfoxide (DMSO), a highly penetrant antiinflammatory agent and purported hydroxyl radical scavenger, was chronically fed to male, weanling Sprague-Dawley rats which were either supplemented with or deficient in Cu. DMSO was found to inhibit the cardiac hypertrophy, anemia and depression of heart Cu concentration which occurs with Cu deficiency. This suggests that the hydroxyl free radical may contribute to the cardiovascular defects caused by dietary Cu deficiency.
已发表的报告表明，铜缺乏会降低抗氧化防御能力，并可能导致组织过氧化。二甲基亚砜（DMSO）是一种具有高度渗透性的抗炎剂，据称是一种羟自由基清除剂，长期喂食给断奶的雄性斯普拉格-道利大鼠，这些大鼠要么补充了铜，要么缺乏铜。结果发现，DMSO可抑制铜缺乏时出现的心脏肥大、贫血以及心脏铜浓度降低。这表明羟自由基可能是饮食中铜缺乏导致心血管缺陷的原因之一。
