Torres M, Barbella Y, Israel A
Faculty of Pharmacy, Department of Biological Science, Universidad Central de Venezuela, Caracas.
Proc Soc Exp Biol Med. 1989 Jan;190(1):18-22. doi: 10.3181/00379727-190-42824.
Intracerebroventricular administration of either rat atrial natriuretic factor (99-126) or dopamine to conscious male hydrated rats resulted in an increase in urinaryvolume and sodium excretion. This activity was prevented, in both cases, by nonselective dopamine antagonist haloperidol (2.5 or 1.25 mg/kg sc, 18 and 2 hr before intracerebroventricular administration of atrial natriuretic factor). Our findings suggest that atrial natriuretic factor exerts its centrally mediated effects on sodium and water metabolism, at least in part, via a dopaminergic mechanism.
向清醒的雄性补水大鼠脑室内注射大鼠心房利钠因子（99 - 126）或多巴胺，会导致尿量和钠排泄增加。在这两种情况下，非选择性多巴胺拮抗剂氟哌啶醇（脑室内注射心房利钠因子前18小时和2小时，皮下注射2.5或1.25 mg/kg）可阻止这种作用。我们的研究结果表明，心房利钠因子至少部分地通过多巴胺能机制对钠和水代谢发挥其中枢介导作用。
