Webb R L, Della Puca R, Manniello J, Robson R D, Zimmerman M B, Ghai R D
Life Sci. 1986 Jun 23;38(25):2319-27. doi: 10.1016/0024-3205(86)90639-9.
Atrial natriuretic factor (ANF) increases sodium (Na+) and water excretion 8-10 fold on repeated administration to anesthetized rats. SCH-23390 (80 micrograms/kg i.v.) and R-sulpiride (80 micrograms/kg i.v.), selective antagonists of dopamine receptors in the renal vasculature, inhibited diuresis and natriuresis induced by AP III and dopamine. These findings suggest that ANF exerts its effects on renal Na+ and water handling via a dopaminergic mechanism; however, changes in intrarenal hemodynamics secondary to dopamine receptor blockade may attenuate the actions of ANF.
心房利钠因子（ANF）在对麻醉大鼠反复给药时可使钠（Na+）和水排泄增加8至10倍。SCH - 23390（静脉注射80微克/千克）和R - 舒必利（静脉注射80微克/千克）是肾血管中多巴胺受体的选择性拮抗剂，它们抑制了AP III和多巴胺诱导的利尿和利钠作用。这些发现表明，ANF通过多巴胺能机制对肾脏的Na+和水代谢发挥作用；然而，多巴胺受体阻断继发的肾内血流动力学变化可能会减弱ANF的作用。
