MSc, Biochemistry Department, Babol University of Medical Sciences, Babol, Iran.
Associate Professor of Biochemistry, Cellular and Molecular Biology Research Centre, Babol University of Medical Sciences, Babol, Iran.
Food Chem. 2011 Jun 15;126(4):1730-3. doi: 10.1016/j.foodchem.2010.12.069. Epub 2010 Dec 22.
The antihyperglycaemic, antihyperlipidemic and antioxidant effects of wild pear (Pyrus biossieriana Buhse) leaf extract were investigated. An alloxan-induced rat model of hyperglycaemia was used to evaluate the antihyperglycaemic, antihyperlipidemic and antioxidant properties of the Pyrus biossieriana Buhse leaf extract. The arbutin content of Pyrus biossieriana Buhse leaves, measured by HPLC, was 12.6 dry weight percent. Administration of the Pyrus biossieriana Buhse leaf extract (at doses of 500 and 1000mg/kg/day) significantly reduced the increase in serum glucose concentration seen in alloxan-treated hyperglycaemic rats. Both concentrations of the extract enhanced serum insulin levels compared to the control group. Both high and low doses of the extract decreased serum triacylglycerol (TG) and cholesterol (CHOL) levels as compared to controls. Serum antioxidant levels were significantly higher in rats treated with low (500mg/kg/day) and high (1000mg/kg/day) doses of Pyrus biossieriana Buhse extracts at 24, 48 and 72h after alloxan injection than in control rats. This study demonstrated that Pyrus biossieriana Buhse leaf extract reduces blood glucose and lipid levels and increases antioxidant status in rats with alloxan-induced hyperglycaemia.
本研究旨在考察野梨（Pyrus biossieriana Buhse）叶提取物的降血糖、降血脂和抗氧化作用。采用四氧嘧啶诱导的大鼠高血糖模型评价了野梨叶提取物的降血糖、降血脂和抗氧化作用。采用 HPLC 法测定野梨叶中熊果苷的含量为 12.6%干重。野梨叶提取物（剂量为 500 和 1000mg/kg/天）给药可显著降低四氧嘧啶诱导的高血糖大鼠血清葡萄糖浓度的升高。与对照组相比，两种浓度的提取物均能提高血清胰岛素水平。与对照组相比，提取物的高、低剂量均能降低血清三酰甘油（TG）和胆固醇（CHOL）水平。与对照组相比，在四氧嘧啶注射后 24、48 和 72 小时，低（500mg/kg/天）和高（1000mg/kg/天）剂量的野梨叶提取物处理的大鼠血清抗氧化水平显著升高。本研究表明，野梨叶提取物可降低四氧嘧啶诱导的高血糖大鼠的血糖和血脂水平，并增加其抗氧化状态。
