用白细胞介素7治疗进行性多灶性白质脑病并接种JC病毒衣壳蛋白VP1疫苗。
Treating progressive multifocal leukoencephalopathy with interleukin 7 and vaccination with JC virus capsid protein VP1.
作者信息
Sospedra Mireia, Schippling Sven, Yousef Sara, Jelcic Ilijas, Bofill-Mas Silvia, Planas Raquel, Stellmann Jan-Patrick, Demina Viktoria, Cinque Paola, Garcea Robert, Croughs Therese, Girones Rosina, Martin Roland
机构信息
Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Neuroimmunology and Multiple Sclerosis Research, Department of Neurology, University of Zurich, Switzerland.
Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
出版信息
Clin Infect Dis. 2014 Dec 1;59(11):1588-92. doi: 10.1093/cid/ciu682. Epub 2014 Sep 11.
Abstract
Progressive multifocal leukoencephalopathy is a currently untreatable infection of the brain. Here, we demonstrate in 2 patients that treatment with interleukin 7, JC polyomavirus (JCV) capsid protein VP1, and a Toll-like receptor 7 agonist used as adjuvant, was well tolerated, and showed a very favorable safety profile and unexpected efficacy that warrant further investigation.
摘要
进行性多灶性白质脑病是一种目前无法治疗的脑部感染。在此，我们在两名患者中证明，使用白细胞介素7、JC多瘤病毒（JCV）衣壳蛋白VP1以及用作佐剂的Toll样受体7激动剂进行治疗，耐受性良好，显示出非常良好的安全性和意外的疗效，值得进一步研究。
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