Lissak A, Sorokin Y, Calderon I, Dirnfeld M, Lioz H, Abramovici H
Department of Obstetrics and Gynecology, Carmel Hospital, Haifa, Israel.
Fertil Steril. 1989 Feb;51(2):247-50. doi: 10.1016/s0015-0282(16)60485-5.
Cimetidine (Tagamet, Smith Klein, Brussels, Belgium) the histamine receptor type 2 blocker, has been suggested as a possible treatment of hirsutism. In a prospective randomized controlled trial, cimetidine 1.5 gm a day was given for 3 months to 12 moderately or severely hirsute women, while 8 other women were randomized to serve as a control group. There was no significant change in the hair growth rate in either group as measured by two assessment methods. This finding suggests that cimetidine, given in the recommended dose for a period of 3 months, does not have a beneficial effect on hirsutism.
西咪替丁（泰胃美，比利时布鲁塞尔史克公司生产），作为一种组胺2型受体阻滞剂，已被提议作为多毛症的一种可能治疗方法。在一项前瞻性随机对照试验中，12名中度或重度多毛的女性每天服用1.5克西咪替丁，持续3个月，而另外8名女性被随机分配作为对照组。通过两种评估方法测量，两组的毛发生长速度均无显著变化。这一发现表明，按照推荐剂量服用3个月的西咪替丁，对多毛症没有有益效果。
