Grandesso R, Spandri P, Gangemi M, Nardelli G B, Ambrosio G B, Conte G, De Salvia D, Meneghetti G
Clin Exp Obstet Gynecol. 1984;11(3):105-9.
The effects on hair growth by treatment with cimetidine have been studied. This drug has been given orally to 4 women with simple hirsutism and 3 women with peptic ulcer as controls for a period of 9 months. Hair growth slowed down in all of the treated women but the results were not statistically significant. A significant decrease in urine 17-ketosteroids has been observed, while plasma levels of testosterone, 17-beta estradiol, progesterone, FSH, LH and prolactin, did not change substantially. It is concluded that, on the whole, cimetidine doses not seem to induce such results on hair growth as to claim a role in the treatment of hirsutism in other current regimes.
已对西咪替丁治疗对毛发生长的影响进行了研究。该药物口服给予4名单纯性多毛症女性和3名消化性溃疡女性作为对照，为期9个月。所有接受治疗的女性毛发生长均减缓，但结果无统计学意义。观察到尿17-酮类固醇显著降低，而睾酮、17-β雌二醇、孕酮、促卵泡激素、促黄体生成素和催乳素的血浆水平没有实质性变化。结论是，总体而言，西咪替丁似乎不会对毛发生长产生足以使其在当前其他治疗方案中宣称可用于治疗多毛症的效果。
