Akiyama M, Zhou O L, Kusunoki Y, Kyoizumi S, Kohno N, Akiba S, Delongchamp R R
Department of Radiobiology, Radiation Effects Research Foundation, Hiroshima, Japan.
Radiat Res. 1989 Jan;117(1):26-34.
The responsiveness of peripheral blood lymphocytes to allogenic antigens in mixed lymphocyte culture (MLC) was measured in 139 atomic-bomb survivors. The study revealed a significant decrease in MLC response with increasing dose of previous radiation exposure. This decline was marked in the survivors who were older than 15 at the time of the bomb (ATB). The results suggest a possible relationship between the recovery of T-cell-related function and the thymic function which processes mature T cells for the immune system. Thus it may be that in the advanced age ATB group, the thymus function had started to involute, allowing less recovery of T-cell function compared to young survivors who had adequate processing T-cell activity.
在139名原子弹爆炸幸存者中测量了外周血淋巴细胞在混合淋巴细胞培养（MLC）中对同种异体抗原的反应性。研究发现，随着既往辐射暴露剂量的增加，MLC反应显著降低。这种下降在原子弹爆炸时年龄超过15岁的幸存者中尤为明显。结果表明，T细胞相关功能的恢复与胸腺功能之间可能存在关联，胸腺功能为免疫系统处理成熟T细胞。因此，在原子弹爆炸时年龄较大的组中，胸腺功能可能已经开始退化，与具有足够T细胞处理活性的年轻幸存者相比，T细胞功能的恢复较少。
