Magrin S, Nouri-Aria K T, Donaldson P T, Wilkinson M L, Portmann B C, Williams R, Eddleston A L
Liver Unit, King's College School of Medicine and Dentistry, London, United Kingdom.
Clin Immunol Immunopathol. 1989 Feb;50(2):205-12. doi: 10.1016/0090-1229(89)90129-3.
Immunoglobulin production in vitro, its control by concanavalin A-activated suppressor T-cells, and the relationship between abnormalities in nonantigen-specific suppression and histocompatibility antigens have been studied in 20 patients with primary sclerosing cholangitis (PSC). Suppression of IgG, IgM, and IgA synthesis was impaired in 12 patients with PSC alone, but was normal in 8 with PSC and associated ulcerative colitis (UC). The HLA antigens B8 and DR3 were increased in frequency in both groups of patients, but an association between DR3, and to a lesser extent B8, and defective suppressor T-cell function was only observed in the patients with PSC alone. These results not only provide further evidence of an association between HLA DR3 and impaired nonantigen-specific suppression but also indicate the genetic complexity of this association and its specificity, being found in this study in only one subgroup of patients with PSC.
对20例原发性硬化性胆管炎（PSC）患者进行了体外免疫球蛋白产生、伴刀豆球蛋白A激活的抑制性T细胞对其的调控以及非抗原特异性抑制异常与组织相容性抗原之间关系的研究。仅患有PSC的12例患者中，IgG、IgM和IgA合成的抑制受损，但8例患有PSC并伴有溃疡性结肠炎（UC）的患者则正常。两组患者中HLA抗原B8和DR3的频率均增加，但仅在仅患有PSC的患者中观察到DR3以及程度较轻的B8与抑制性T细胞功能缺陷之间存在关联。这些结果不仅进一步证明了HLA DR3与非抗原特异性抑制受损之间存在关联，还表明了这种关联的遗传复杂性及其特异性，在本研究中仅在PSC患者的一个亚组中发现。
