Vuento R, Eskola J, Leino R, Koskimies S, Viander M
Scand J Immunol. 1983 Dec;18(6):551-5. doi: 10.1111/j.1365-3083.1983.tb00890.x.
The histocompatibility antigens B8 and DR3 are associated with several autoimmune diseases, and immune hyper-responsiveness has been believed to be one factor in the pathogenesis of these diseases. In the present study we compared the in vitro immunoglobulin production of healthy HLA-B8-positive individuals with that of HLA-B8-negative individuals. In HLA-B8-positive persons a higher number of pokeweed mitogen (PWM)-stimulated Ig-secreting cells was obtained. When the cells were stimulated with PWM in the presence of a physiological concentration of hydrocortisone (HC), the secretion of IgG was significantly higher in HLA-B8-positive individuals. This finding indicates that the PWM-stimulated IgG secretion in healthy HLA-B8-positive individuals is more sensitive for the enhancing action of HC.
组织相容性抗原B8和DR3与多种自身免疫性疾病相关，免疫反应过度被认为是这些疾病发病机制中的一个因素。在本研究中，我们比较了健康的HLA - B8阳性个体和HLA - B8阴性个体的体外免疫球蛋白产生情况。在HLA - B8阳性人群中，获得了更多经商陆有丝分裂原（PWM）刺激的免疫球蛋白分泌细胞。当细胞在生理浓度的氢化可的松（HC）存在下用PWM刺激时，HLA - B8阳性个体的IgG分泌显著更高。这一发现表明，健康的HLA - B8阳性个体中PWM刺激的IgG分泌对HC的增强作用更敏感。
