Franklin K, Pollari F, Marshall B J, Pintar K D M, Nesbitt A, Young I, McEwen S A, Vanderlaan J, Papadopoulos A
Department of Population Medicine,Ontario Veterinary College, University of Guelph,Guelph,ON,Canada.
Centre for Food-borne,Environmental and Zoonotic Infectious Diseases,Public Health Agency of Canada,Guelph,ON,Canada.
Epidemiol Infect. 2015 May;143(7):1368-76. doi: 10.1017/S0950268814002027. Epub 2014 Sep 12.
Laboratory-based surveillance data is essential for monitoring trends in the incidence of enteric disease. Current Canadian human enteric surveillance systems report only confirmed cases of human enteric disease and are often unable to capture the number of negative test results. Data from 9116 hospital stool specimens from the Waterloo Region in Canada, with a mixed urban and rural population of about 500 000 were analysed to investigate the use of stool submission data and its role in reporting bias when determining the incidence of enteric disease. The proportion of stool specimens positive for Campylobacter spp. was highest in the 15-29 years age group, and in the 5-14 years age group for Salmonella spp. and E. coli O157:H7. By contrast, the age-specific incidence rates were highest for all three pathogens in the 0-4 years age group which also had the highest stool submission rate. This suggests that variations in age-specific stool submission rates are influencing current interpretation of surveillance data.
基于实验室的监测数据对于监测肠道疾病发病率趋势至关重要。加拿大目前的人类肠道监测系统仅报告人类肠道疾病确诊病例，且往往无法获取阴性检测结果的数量。对来自加拿大滑铁卢地区9116份医院粪便标本的数据进行了分析，该地区城乡混合人口约50万，旨在研究粪便送检数据的用途及其在确定肠道疾病发病率时对报告偏倚的影响。弯曲杆菌属粪便标本阳性比例在15 - 29岁年龄组最高，沙门氏菌属和大肠杆菌O157:H7在5 - 14岁年龄组最高。相比之下，所有三种病原体的年龄别发病率在0 - 4岁年龄组最高，该年龄组的粪便送检率也最高。这表明年龄别粪便送检率的差异正在影响当前对监测数据的解读。
