Zhukhovitskaya Alisa, Battaglia Danielle, Khosla Sid M, Murry Thomas, Sulica Lucian
Department of Surgery, North Shore - Long Island Jewish Health System, Bronx.
Laryngoscope. 2015 Jan;125(1):191-6. doi: 10.1002/lary.24911. Epub 2014 Sep 12.
OBJECTIVE/HYPOTHESIS: Certain lesions appear to occur predominantly in one gender or in younger or older patients. We examined a large sample from a treatment-seeking population to describe gender and age associations of an array of benign vocal fold lesions.
Retrospective review.
The medical records and evaluations of all adult patients presenting for care over a 5-year period were examined for demographic characteristics and lesion type. A total of 641 lesions in 602 patients were grouped into 13 broad categories, and prevalence was compared between male and female patients and three age groups.
Pseudocysts and bilateral midfold lesions occurred principally in young (18-39 years old) females (P < 0.0001). Reinke's edema was found in older (> 39 years old) women (P < 0.012). Polyps, contact lesions, leukoplakia (all P < 0.0001), and sulcus (P < 0.0002) were found predominantly in men.
Certain benign mucosal lesions are strongly associated with age and especially with gender. These differences may be explained by intrinsic differences in laryngeal anatomy and phonatory physiology in these groups, including differences in phonatory frequency and air pressure, and in the ability of the membranous vocal fold to withstand phonotrauma. Such inherent differences have implications for treatment expectations and approaches.
目的/假设：某些病变似乎主要发生在某一性别或年轻或年长患者中。我们对大量寻求治疗的人群样本进行了研究，以描述一系列良性声带病变与性别和年龄的关联。
回顾性研究。
检查了5年期间所有前来就诊的成年患者的病历和评估结果，以了解其人口统计学特征和病变类型。602例患者中的641个病变被分为13大类，并比较了男性和女性患者以及三个年龄组之间的患病率。
假性囊肿和双侧声带中份病变主要发生在年轻（18 - 39岁）女性中（P < 0.0001）。老年（> 39岁）女性中发现了任克氏水肿（P < 0.012）。息肉、接触性病变、白斑（均P < 0.0001）和沟状病变（P < 0.0002）主要见于男性。
某些良性黏膜病变与年龄尤其是性别密切相关。这些差异可能由这些人群喉部解剖结构和发声生理学的内在差异所解释，包括发声频率和气压的差异，以及膜性声带承受发声创伤的能力差异。这种内在差异对治疗预期和方法有影响。
